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b'<html>\n\t<head>\n\t\t<meta charset="utf-8" />\n <meta name="googlebot" content="noindex,indexifembedded" />\n\t\t<title></title>\n\t\t<link href="../assets/css/style-document.css" rel="stylesheet">\n\t\t<link href="https://fonts.googleapis.com/css2?family=Roboto:ital,wght@0,100;0,300;0,400;0,500;0,700;0,900;1,100;1,300;1,400;1,500;1,700;1,900&display=swap" rel="stylesheet" />\n\t\t<script type="application/javascript" src="../assets/js/doc.index.js"></script>\n\t</head>\n\t<body data-cy="das-document-body" class="das-document-body">\n <div class="body-inner">\n <div class="das-document-container-top">\n <div class="das-document-wrap">\n\t <div class="document-header">\n <h4>Toxicological information</h4>\n </div>\n <div class="das-doc-content-container">\n <div class="document-header__section-links">\n <span class="section-links-label">Jump to </span>\n <div class="document-header__section-links-items">\n <ul data-cy="section-link-list" class="section-link-list" id="section-link-list"></ul>\n </div>\n <div class="document-header__section-actions">\n <span onclick="scrollTabs(\'left\', this)" class="section-link-action section-link-action-left"></span>\n <span onclick="scrollTabs(\'right\', this)" class="section-link-action section-link-action-right"></span>\n </div>\n </div>\n <article data-cy="das-document" class="das-document ENDPOINT_SUMMARY DataTox" id="IUC5-5f55d8ec-7a71-4e2c-9955-8469ead9fe84/0035f3f8-7467-4944-9028-1db2e9c99565">\n <div class="das-doc-toolbar">\n <div class="form-check form-switch das-toolbar-item">\n <input id="das-empty-elements-toggle" type="checkbox" class="das-checkbox-toggle" />\n <label onclick="toggleEmptyFields()" for="das-empty-elements-toggle" class="das-toggle">Hide empty fields</label>\n </div>\n </div>\n <section data-cy="das-block" class="das-block AdministrativeDataSummary das-block_empty"\n id="38c9cb03-e02c-4b10-941a-d565a75dda28"\n> <h3 class="das-block_label">\n Administrative data\n </h3>\n\t\t<div class="das-field_label DataProtection das-empty-value das-empty-label">\n\t\t\t\n\t\t</div>\n <div data-cy="das-field_data-protection" class="das-field das-field_data-protection das-field_no-value">\n <div class="das-field_label">Confidentiality</div>\n\t\t\t<div class="das-field_value das-value_data-protection">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t\t</div>\n\t\t</div>\n\t\t<div data-cy="das-field_data-protection" class="das-field das-field_data-protection das-field_no-value">\n <div class="das-field_label">Justification</div>\n\t\t\t<div class="das-field_value das-value_data-protection">\n\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\n\t\t\t\t</dl>\n\t\t\t</div>\n\t\t</div>\n\t\t<div data-cy="das-field_data-protection" class="das-field das-field_data-protection das-field_no-value">\n <div class="das-field_label">Use restricted to selected regulatory programmes</div>\n\t\t\t<div class="das-field_value das-value_data-protection">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t\t</div>\n\t\t</div>\n</section> <section data-cy="das-block" class="das-block WorkersHazardViaInhalationRoute "\n id="1be86cda-4d65-4732-a8bc-5186e9be72ff"\n> <h3 class="das-block_label">\n Workers - Hazard via inhalation route\n </h3>\n <section data-cy="das-block" class="das-block SystemicEffects "\n id="f877e0e9-208f-4ce4-b3b2-a7717db0422a"\n> <h3 class="das-block_label">\n Systemic effects\n </h3>\n <section data-cy="das-block" class="das-block LongTermStudy "\n id="514eb9a2-b634-44b1-8c25-eb5c5ca699fc"\n> <h3 class="das-block_label">\n Long term exposure\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label HazardAssessment">\n\t\t\tHazard assessment conclusion\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">DNEL (Derived No Effect Level)</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity ">\n\t\t<div class="das-field_label StDose">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value">77</span>\t\t<span class="unit">\n\t\t\t <span class="phrase ">mg/m\xc2\xb3</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label MostSensitiveEndpoint">\n\t\t\tMost sensitive endpoint\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">repeated dose toxicity</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label OriginalStudy das-empty-value">\n\t\t\tRoute of original study\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n <section data-cy="das-block" class="das-block DNMELInfoWithRTR "\n id="6ea6dbd5-2dba-408c-8876-4897d422f146"\n> <h3 class="das-block_label">\n DNEL related information\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DerivationMethod das-empty-value">\n\t\t\tDNEL derivation method\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal ">\n\t\t<div class="das-field_label AssessmentFactor">\n\t\t\tOverall assessment factor (AF)\n\t\t</div>\n <div class="das-field_value">\n3 </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DoseDescriptorStartingPoint das-empty-value">\n\t\t\tDose descriptor starting point\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label DoseDescriptorStartRTR">\n\t\t\tModified dose descriptor starting point\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">NOAEC</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDoseRTR das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label JustificationRTR das-empty-value">\n\t\t\tExplanation for the modification of the dose descriptor starting point\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> [Empty] </span>\t\t\t</div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DoseResponseAF das-empty-value">\n\t\t\tAF for dose response relationship\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DoseResponseJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DiffInDurationAF das-empty-value">\n\t\t\tAF for differences in duration of exposure\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DiffInDurationJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label InterspeciesAF das-empty-value">\n\t\t\tAF for interspecies differences (allometric scaling)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label InterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesAF das-empty-value">\n\t\t\tAF for other interspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesAF das-empty-value">\n\t\t\tAF for intraspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DatabaseQualityAF das-empty-value">\n\t\t\tAF for the quality of the whole database\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DatabaseJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthUncertaintiesAF das-empty-value">\n\t\t\tAF for remaining uncertainties\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label OthUncertaintiesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n</section> <section data-cy="das-block" class="das-block ExplanationForHazardConclusion das-block_empty"\n id="1ee59df6-1dc8-4b4a-8f08-af9f42f594f5"\n> <h3 class="das-block_label">\n Explanation for hazard conclusion\n </h3>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label JustificationAndComments das-empty-value">\n\t\t\tExplanation for hazard conclusion\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> <span class="das-redacted-icon"> <svg xmlns="http://www.w3.org/2000/svg" width="15.233" height="15.431" viewBox="0 0 15.233 15.431"> <g id="conf_flag" transform="translate(-107.9 -1.299)"> <path id="Path_394" data-name="Path 394" d="M109.832,9.81a38.965,38.965,0,0,0,5-1.761.688.688,0,0,1,.691-.043.617.617,0,0,1,.218.345,1.692,1.692,0,0,0,.1.276l.007-.011s0,0,0,.006l1.363-2.285a.245.245,0,0,1,.214-.126.242.242,0,0,1,.227.152l1.878,3.076a9.2,9.2,0,0,0,1.579-.445.5.5,0,0,0,.325-.475l-.021-5.158a.507.507,0,0,0-.6-.5c-.869.156-2.34.336-2.34.336-1.891.263-2.691-.436-2.963-.777a.876.876,0,0,1-.109-.167c-.381-.753-1.8-.954-3.2-.956a21.453,21.453,0,0,0-2.661.184,1.457,1.457,0,0,0-.687-.158,1.7,1.7,0,0,0-.282.023c-.383.062-.665.252-.68.473h0V15.233l0,.006v.148a.545.545,0,0,0,.122.344l.454.556a.542.542,0,0,0,.858-.024l.392-.539a.54.54,0,0,0,.1-.319V10.158l0-.141V9.81Zm0-7.612c2.308,2.456.5,6.4,0,7.377Z" transform="translate(0 0)" fill="#ed1156"/> <path id="Path_395" data-name="Path 395" d="M333.622,334.784l-5.485-8.977a.175.175,0,0,0-.161-.107.179.179,0,0,0-.126.053.161.161,0,0,0-.026.036l-5.359,8.983a.181.181,0,0,0,0,.192.174.174,0,0,0,.16.075h10.817a.173.173,0,0,0,.173-.077A.175.175,0,0,0,333.622,334.784Zm-5.164-.837a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-.5a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Zm0-1.763a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-2.876a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Z" transform="translate(-210.509 -318.31)" fill="#ed1156"/> </g> </svg> </span> <span class="das-redacted-value"> [Not publishable] </span> </span>\t\t\t</div>\n </div>\n</section></section> <section data-cy="das-block" class="das-block AcuteShortTermExposureStudy "\n id="695d3506-10f2-4522-9e60-655132cd678e"\n> <h3 class="das-block_label">\n Acute/short term exposure\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label HazardAssessment">\n\t\t\tHazard assessment conclusion\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">low hazard (no threshold derived)</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label MostSensitiveEndpoint das-empty-value">\n\t\t\tMost sensitive endpoint\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label OriginalStudy das-empty-value">\n\t\t\tRoute of original study\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n <section data-cy="das-block" class="das-block DNELInfoWithRouteToRouteWithExtrapolation "\n id="b43f7e94-085e-415e-ac52-d2477515b021"\n> <h3 class="das-block_label">\n DNEL related information\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DerivationMethod das-empty-value">\n\t\t\tDNEL derivation method\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OverallAssessmentFactor das-empty-value">\n\t\t\tOverall assessment factor (AF)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n\t <div class="das-field das-field_checkbox">\n\t\t<div class="das-field_label Extrapolated">\n\t\t\tDNEL extrapolated from long term DNEL\n\t\t</div>\n <div class="das-field_value">\n <span data-cy="das-value_checkbox-unchecked" class="das-value_checkbox-unchecked"></span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DoseDescriptorStartingPoint das-empty-value">\n\t\t\tDose descriptor starting point\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DoseDescriptorStartRTR das-empty-value">\n\t\t\tModified dose descriptor starting point\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDoseRTR das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label DoseDescriptorJustificationRTR das-empty-value">\n\t\t\tExplanation for the modification of the dose descriptor starting point\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> [Empty] </span>\t\t\t</div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DoseResponseAF das-empty-value">\n\t\t\tAF for dose response relationship\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DoseResponseJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label InterspeciesAF das-empty-value">\n\t\t\tAF for interspecies differences (allometric scaling)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label InterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesAF das-empty-value">\n\t\t\tAF for other interspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesAF das-empty-value">\n\t\t\tAF for intraspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesJustifAF das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DatabaseQualityDatabaseQualityAF das-empty-value">\n\t\t\tAF for the quality of the whole database\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DatabaseQualityJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthUncertaintiesAF das-empty-value">\n\t\t\tAF for remaining uncertainties\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label UncertaintiesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n</section> <section data-cy="das-block" class="das-block ExplanationForHazardConclusion das-block_empty"\n id="ebbb8abc-e8d1-46d0-8391-1c3f1ce98d28"\n> <h3 class="das-block_label">\n Explanation for hazard conclusion\n </h3>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label JustificationAndComments das-empty-value">\n\t\t\tExplanation for hazard conclusion\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> <span class="das-redacted-icon"> <svg xmlns="http://www.w3.org/2000/svg" width="15.233" height="15.431" viewBox="0 0 15.233 15.431"> <g id="conf_flag" transform="translate(-107.9 -1.299)"> <path id="Path_394" data-name="Path 394" d="M109.832,9.81a38.965,38.965,0,0,0,5-1.761.688.688,0,0,1,.691-.043.617.617,0,0,1,.218.345,1.692,1.692,0,0,0,.1.276l.007-.011s0,0,0,.006l1.363-2.285a.245.245,0,0,1,.214-.126.242.242,0,0,1,.227.152l1.878,3.076a9.2,9.2,0,0,0,1.579-.445.5.5,0,0,0,.325-.475l-.021-5.158a.507.507,0,0,0-.6-.5c-.869.156-2.34.336-2.34.336-1.891.263-2.691-.436-2.963-.777a.876.876,0,0,1-.109-.167c-.381-.753-1.8-.954-3.2-.956a21.453,21.453,0,0,0-2.661.184,1.457,1.457,0,0,0-.687-.158,1.7,1.7,0,0,0-.282.023c-.383.062-.665.252-.68.473h0V15.233l0,.006v.148a.545.545,0,0,0,.122.344l.454.556a.542.542,0,0,0,.858-.024l.392-.539a.54.54,0,0,0,.1-.319V10.158l0-.141V9.81Zm0-7.612c2.308,2.456.5,6.4,0,7.377Z" transform="translate(0 0)" fill="#ed1156"/> <path id="Path_395" data-name="Path 395" d="M333.622,334.784l-5.485-8.977a.175.175,0,0,0-.161-.107.179.179,0,0,0-.126.053.161.161,0,0,0-.026.036l-5.359,8.983a.181.181,0,0,0,0,.192.174.174,0,0,0,.16.075h10.817a.173.173,0,0,0,.173-.077A.175.175,0,0,0,333.622,334.784Zm-5.164-.837a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-.5a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Zm0-1.763a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-2.876a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Z" transform="translate(-210.509 -318.31)" fill="#ed1156"/> </g> </svg> </span> <span class="das-redacted-value"> [Not publishable] </span> </span>\t\t\t</div>\n </div>\n</section></section></section> <section data-cy="das-block" class="das-block LocalEffects "\n id="4243cb2e-9d28-4cfe-9949-dd68d94b89e2"\n> <h3 class="das-block_label">\n Local effects\n </h3>\n <section data-cy="das-block" class="das-block LongTermNoStudy "\n id="69e8d0f1-b3fb-4ccc-989a-9ab46211c610"\n> <h3 class="das-block_label">\n Long term exposure\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label HazardAssessment">\n\t\t\tHazard assessment conclusion\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">no hazard identified</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label MostSensitiveEndpoint das-empty-value">\n\t\t\tMost sensitive endpoint\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n <section data-cy="das-block" class="das-block DNMELInfoWithoutRTR das-block_empty"\n id="9c9cb806-41c7-4612-9959-fc50f4e9cd88"\n> <h3 class="das-block_label">\n DNEL related information\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DerivationMethod das-empty-value">\n\t\t\tDNEL derivation method\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label AssessmentFactor das-empty-value">\n\t\t\tOverall assessment factor (AF)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DoseDescriptorStart das-empty-value">\n\t\t\tDose descriptor\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DoseResponseAF das-empty-value">\n\t\t\tAF for dose response relationship\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DoseResponseJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DiffInDurationAF das-empty-value">\n\t\t\tAF for differences in duration of exposure\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DiffInDurationJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label InterspeciesAF das-empty-value">\n\t\t\tAF for interspecies differences (allometric scaling)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label InterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesAF das-empty-value">\n\t\t\tAF for other interspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesAF das-empty-value">\n\t\t\tAF for intraspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DatabaseQualityAF das-empty-value">\n\t\t\tAF for the quality of the whole database\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DatabaseJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthUncertaintiesAF das-empty-value">\n\t\t\tAF for remaining uncertainties\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label OthUncertaintiesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n</section> <section data-cy="das-block" class="das-block ExplanationForHazardConclusion das-block_empty"\n id="65f8f662-0182-41ef-9947-00d8160bbdd7"\n> <h3 class="das-block_label">\n Explanation for hazard conclusion\n </h3>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label JustificationAndComments das-empty-value">\n\t\t\tExplanation for hazard conclusion\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> <span class="das-redacted-icon"> <svg xmlns="http://www.w3.org/2000/svg" width="15.233" height="15.431" viewBox="0 0 15.233 15.431"> <g id="conf_flag" transform="translate(-107.9 -1.299)"> <path id="Path_394" data-name="Path 394" d="M109.832,9.81a38.965,38.965,0,0,0,5-1.761.688.688,0,0,1,.691-.043.617.617,0,0,1,.218.345,1.692,1.692,0,0,0,.1.276l.007-.011s0,0,0,.006l1.363-2.285a.245.245,0,0,1,.214-.126.242.242,0,0,1,.227.152l1.878,3.076a9.2,9.2,0,0,0,1.579-.445.5.5,0,0,0,.325-.475l-.021-5.158a.507.507,0,0,0-.6-.5c-.869.156-2.34.336-2.34.336-1.891.263-2.691-.436-2.963-.777a.876.876,0,0,1-.109-.167c-.381-.753-1.8-.954-3.2-.956a21.453,21.453,0,0,0-2.661.184,1.457,1.457,0,0,0-.687-.158,1.7,1.7,0,0,0-.282.023c-.383.062-.665.252-.68.473h0V15.233l0,.006v.148a.545.545,0,0,0,.122.344l.454.556a.542.542,0,0,0,.858-.024l.392-.539a.54.54,0,0,0,.1-.319V10.158l0-.141V9.81Zm0-7.612c2.308,2.456.5,6.4,0,7.377Z" transform="translate(0 0)" fill="#ed1156"/> <path id="Path_395" data-name="Path 395" d="M333.622,334.784l-5.485-8.977a.175.175,0,0,0-.161-.107.179.179,0,0,0-.126.053.161.161,0,0,0-.026.036l-5.359,8.983a.181.181,0,0,0,0,.192.174.174,0,0,0,.16.075h10.817a.173.173,0,0,0,.173-.077A.175.175,0,0,0,333.622,334.784Zm-5.164-.837a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-.5a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Zm0-1.763a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-2.876a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Z" transform="translate(-210.509 -318.31)" fill="#ed1156"/> </g> </svg> </span> <span class="das-redacted-value"> [Not publishable] </span> </span>\t\t\t</div>\n </div>\n</section></section> <section data-cy="das-block" class="das-block AcuteShortTermExposureStudy "\n id="765e299f-b7f0-4bc0-a370-1b237e9ace06"\n> <h3 class="das-block_label">\n Acute/short term exposure\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label HazardAssessment">\n\t\t\tHazard assessment conclusion\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">DNEL (Derived No Effect Level)</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity ">\n\t\t<div class="das-field_label StDose">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value">293</span>\t\t<span class="unit">\n\t\t\t <span class="phrase ">mg/m\xc2\xb3</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label MostSensitiveEndpoint">\n\t\t\tMost sensitive endpoint\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">irritation (respiratory tract)</span>\n\t\t</span>\n </div>\n </div>\n <section data-cy="das-block" class="das-block DNELInfoWithoutRouteToRouteWithExtrapolation "\n id="31dd3f92-decc-4969-b5f8-b874292174b4"\n> <h3 class="das-block_label">\n DNEL related information\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DerivationMethod das-empty-value">\n\t\t\tDNEL derivation method\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal ">\n\t\t<div class="das-field_label OverallAssessmentFactor">\n\t\t\tOverall assessment factor (AF)\n\t\t</div>\n <div class="das-field_value">\n3 </div>\n\t\t</div>\n\t <div class="das-field das-field_checkbox">\n\t\t<div class="das-field_label Extrapolated">\n\t\t\tDNEL extrapolated from long term DNEL\n\t\t</div>\n <div class="das-field_value">\n <span data-cy="das-value_checkbox-unchecked" class="das-value_checkbox-unchecked"></span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label DoseDescriptorStart">\n\t\t\tDose descriptor starting point\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">NOAEC</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DoseResponseAF das-empty-value">\n\t\t\tAF for dose response relationship\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DoseResponseJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label InterspeciesAF das-empty-value">\n\t\t\tAF for interspecies differences (allometric scaling)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label InterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesAF das-empty-value">\n\t\t\tAF for other interspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesAF das-empty-value">\n\t\t\tAF for intraspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesJustifAF das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DatabaseQualityDatabaseQualityAF das-empty-value">\n\t\t\tAF for the quality of the whole database\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DatabaseQualityJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthUncertaintiesAF das-empty-value">\n\t\t\tAF for remaining uncertainties\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label UncertaintiesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n</section> <section data-cy="das-block" class="das-block ExplanationForHazardConclusion das-block_empty"\n id="195b08ac-d98d-4070-8912-02cb23d0046d"\n> <h3 class="das-block_label">\n Explanation for hazard conclusion\n </h3>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label JustificationAndComments das-empty-value">\n\t\t\tExplanation for hazard conclusion\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> <span class="das-redacted-icon"> <svg xmlns="http://www.w3.org/2000/svg" width="15.233" height="15.431" viewBox="0 0 15.233 15.431"> <g id="conf_flag" transform="translate(-107.9 -1.299)"> <path id="Path_394" data-name="Path 394" d="M109.832,9.81a38.965,38.965,0,0,0,5-1.761.688.688,0,0,1,.691-.043.617.617,0,0,1,.218.345,1.692,1.692,0,0,0,.1.276l.007-.011s0,0,0,.006l1.363-2.285a.245.245,0,0,1,.214-.126.242.242,0,0,1,.227.152l1.878,3.076a9.2,9.2,0,0,0,1.579-.445.5.5,0,0,0,.325-.475l-.021-5.158a.507.507,0,0,0-.6-.5c-.869.156-2.34.336-2.34.336-1.891.263-2.691-.436-2.963-.777a.876.876,0,0,1-.109-.167c-.381-.753-1.8-.954-3.2-.956a21.453,21.453,0,0,0-2.661.184,1.457,1.457,0,0,0-.687-.158,1.7,1.7,0,0,0-.282.023c-.383.062-.665.252-.68.473h0V15.233l0,.006v.148a.545.545,0,0,0,.122.344l.454.556a.542.542,0,0,0,.858-.024l.392-.539a.54.54,0,0,0,.1-.319V10.158l0-.141V9.81Zm0-7.612c2.308,2.456.5,6.4,0,7.377Z" transform="translate(0 0)" fill="#ed1156"/> <path id="Path_395" data-name="Path 395" d="M333.622,334.784l-5.485-8.977a.175.175,0,0,0-.161-.107.179.179,0,0,0-.126.053.161.161,0,0,0-.026.036l-5.359,8.983a.181.181,0,0,0,0,.192.174.174,0,0,0,.16.075h10.817a.173.173,0,0,0,.173-.077A.175.175,0,0,0,333.622,334.784Zm-5.164-.837a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-.5a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Zm0-1.763a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-2.876a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Z" transform="translate(-210.509 -318.31)" fill="#ed1156"/> </g> </svg> </span> <span class="das-redacted-value"> [Not publishable] </span> </span>\t\t\t</div>\n </div>\n</section></section></section></section> <section data-cy="das-block" class="das-block WorkersHazardViaDermalRoute "\n id="dfbde857-93c2-42d7-a37c-820b1ce3f5bb"\n> <h3 class="das-block_label">\n Workers - Hazard via dermal route\n </h3>\n <section data-cy="das-block" class="das-block SystemicEffects "\n id="c6070eb2-9def-46c2-941a-d6a78387b5be"\n> <h3 class="das-block_label">\n Systemic effects\n </h3>\n <section data-cy="das-block" class="das-block LongTermStudy "\n id="db9db07d-3277-4add-8e9e-305ffda946aa"\n> <h3 class="das-block_label">\n Long term exposure\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label HazardAssessment">\n\t\t\tHazard assessment conclusion\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">DNEL (Derived No Effect Level)</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity ">\n\t\t<div class="das-field_label StDose">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value">180</span>\t\t<span class="unit">\n\t\t\t <span class="phrase ">mg/kg bw/day</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label MostSensitiveEndpoint">\n\t\t\tMost sensitive endpoint\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">repeated dose toxicity</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label OriginalStudy das-empty-value">\n\t\t\tRoute of original study\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n <section data-cy="das-block" class="das-block DNMELInfoWithRTR "\n id="12ef6441-378f-40e6-8651-9635ab892eb0"\n> <h3 class="das-block_label">\n DNEL related information\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DerivationMethod das-empty-value">\n\t\t\tDNEL derivation method\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal ">\n\t\t<div class="das-field_label AssessmentFactor">\n\t\t\tOverall assessment factor (AF)\n\t\t</div>\n <div class="das-field_value">\n12 </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DoseDescriptorStartingPoint das-empty-value">\n\t\t\tDose descriptor starting point\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label DoseDescriptorStartRTR">\n\t\t\tModified dose descriptor starting point\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">NOAEL</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDoseRTR das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label JustificationRTR das-empty-value">\n\t\t\tExplanation for the modification of the dose descriptor starting point\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> [Empty] </span>\t\t\t</div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DoseResponseAF das-empty-value">\n\t\t\tAF for dose response relationship\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DoseResponseJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DiffInDurationAF das-empty-value">\n\t\t\tAF for differences in duration of exposure\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DiffInDurationJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label InterspeciesAF das-empty-value">\n\t\t\tAF for interspecies differences (allometric scaling)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label InterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesAF das-empty-value">\n\t\t\tAF for other interspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesAF das-empty-value">\n\t\t\tAF for intraspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DatabaseQualityAF das-empty-value">\n\t\t\tAF for the quality of the whole database\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DatabaseJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthUncertaintiesAF das-empty-value">\n\t\t\tAF for remaining uncertainties\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label OthUncertaintiesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n</section> <section data-cy="das-block" class="das-block ExplanationForHazardConclusion das-block_empty"\n id="7e811ef3-b073-4a2f-878c-6427f0a3cb84"\n> <h3 class="das-block_label">\n Explanation for hazard conclusion\n </h3>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label JustificationAndComments das-empty-value">\n\t\t\tExplanation for hazard conclusion\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> <span class="das-redacted-icon"> <svg xmlns="http://www.w3.org/2000/svg" width="15.233" height="15.431" viewBox="0 0 15.233 15.431"> <g id="conf_flag" transform="translate(-107.9 -1.299)"> <path id="Path_394" data-name="Path 394" d="M109.832,9.81a38.965,38.965,0,0,0,5-1.761.688.688,0,0,1,.691-.043.617.617,0,0,1,.218.345,1.692,1.692,0,0,0,.1.276l.007-.011s0,0,0,.006l1.363-2.285a.245.245,0,0,1,.214-.126.242.242,0,0,1,.227.152l1.878,3.076a9.2,9.2,0,0,0,1.579-.445.5.5,0,0,0,.325-.475l-.021-5.158a.507.507,0,0,0-.6-.5c-.869.156-2.34.336-2.34.336-1.891.263-2.691-.436-2.963-.777a.876.876,0,0,1-.109-.167c-.381-.753-1.8-.954-3.2-.956a21.453,21.453,0,0,0-2.661.184,1.457,1.457,0,0,0-.687-.158,1.7,1.7,0,0,0-.282.023c-.383.062-.665.252-.68.473h0V15.233l0,.006v.148a.545.545,0,0,0,.122.344l.454.556a.542.542,0,0,0,.858-.024l.392-.539a.54.54,0,0,0,.1-.319V10.158l0-.141V9.81Zm0-7.612c2.308,2.456.5,6.4,0,7.377Z" transform="translate(0 0)" fill="#ed1156"/> <path id="Path_395" data-name="Path 395" d="M333.622,334.784l-5.485-8.977a.175.175,0,0,0-.161-.107.179.179,0,0,0-.126.053.161.161,0,0,0-.026.036l-5.359,8.983a.181.181,0,0,0,0,.192.174.174,0,0,0,.16.075h10.817a.173.173,0,0,0,.173-.077A.175.175,0,0,0,333.622,334.784Zm-5.164-.837a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-.5a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Zm0-1.763a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-2.876a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Z" transform="translate(-210.509 -318.31)" fill="#ed1156"/> </g> </svg> </span> <span class="das-redacted-value"> [Not publishable] </span> </span>\t\t\t</div>\n </div>\n</section></section> <section data-cy="das-block" class="das-block AcuteShortTermExposureStudy "\n id="ad73dd25-b5bd-4928-bb23-6440208f24ad"\n> <h3 class="das-block_label">\n Acute/short term exposure\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label HazardAssessment">\n\t\t\tHazard assessment conclusion\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">no hazard identified</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label MostSensitiveEndpoint das-empty-value">\n\t\t\tMost sensitive endpoint\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label OriginalStudy das-empty-value">\n\t\t\tRoute of original study\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n <section data-cy="das-block" class="das-block DNELInfoWithRouteToRouteWithExtrapolation "\n id="c263930f-6099-4fb0-bdca-b478994b56a5"\n> <h3 class="das-block_label">\n DNEL related information\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DerivationMethod das-empty-value">\n\t\t\tDNEL derivation method\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OverallAssessmentFactor das-empty-value">\n\t\t\tOverall assessment factor (AF)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n\t <div class="das-field das-field_checkbox">\n\t\t<div class="das-field_label Extrapolated">\n\t\t\tDNEL extrapolated from long term DNEL\n\t\t</div>\n <div class="das-field_value">\n <span data-cy="das-value_checkbox-unchecked" class="das-value_checkbox-unchecked"></span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DoseDescriptorStartingPoint das-empty-value">\n\t\t\tDose descriptor starting point\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DoseDescriptorStartRTR das-empty-value">\n\t\t\tModified dose descriptor starting point\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDoseRTR das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label DoseDescriptorJustificationRTR das-empty-value">\n\t\t\tExplanation for the modification of the dose descriptor starting point\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> [Empty] </span>\t\t\t</div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DoseResponseAF das-empty-value">\n\t\t\tAF for dose response relationship\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DoseResponseJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label InterspeciesAF das-empty-value">\n\t\t\tAF for interspecies differences (allometric scaling)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label InterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesAF das-empty-value">\n\t\t\tAF for other interspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesAF das-empty-value">\n\t\t\tAF for intraspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesJustifAF das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DatabaseQualityDatabaseQualityAF das-empty-value">\n\t\t\tAF for the quality of the whole database\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DatabaseQualityJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthUncertaintiesAF das-empty-value">\n\t\t\tAF for remaining uncertainties\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label UncertaintiesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n</section> <section data-cy="das-block" class="das-block ExplanationForHazardConclusion das-block_empty"\n id="5c63775f-72cd-4436-a108-b3b95384082e"\n> <h3 class="das-block_label">\n Explanation for hazard conclusion\n </h3>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label JustificationAndComments das-empty-value">\n\t\t\tExplanation for hazard conclusion\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> <span class="das-redacted-icon"> <svg xmlns="http://www.w3.org/2000/svg" width="15.233" height="15.431" viewBox="0 0 15.233 15.431"> <g id="conf_flag" transform="translate(-107.9 -1.299)"> <path id="Path_394" data-name="Path 394" d="M109.832,9.81a38.965,38.965,0,0,0,5-1.761.688.688,0,0,1,.691-.043.617.617,0,0,1,.218.345,1.692,1.692,0,0,0,.1.276l.007-.011s0,0,0,.006l1.363-2.285a.245.245,0,0,1,.214-.126.242.242,0,0,1,.227.152l1.878,3.076a9.2,9.2,0,0,0,1.579-.445.5.5,0,0,0,.325-.475l-.021-5.158a.507.507,0,0,0-.6-.5c-.869.156-2.34.336-2.34.336-1.891.263-2.691-.436-2.963-.777a.876.876,0,0,1-.109-.167c-.381-.753-1.8-.954-3.2-.956a21.453,21.453,0,0,0-2.661.184,1.457,1.457,0,0,0-.687-.158,1.7,1.7,0,0,0-.282.023c-.383.062-.665.252-.68.473h0V15.233l0,.006v.148a.545.545,0,0,0,.122.344l.454.556a.542.542,0,0,0,.858-.024l.392-.539a.54.54,0,0,0,.1-.319V10.158l0-.141V9.81Zm0-7.612c2.308,2.456.5,6.4,0,7.377Z" transform="translate(0 0)" fill="#ed1156"/> <path id="Path_395" data-name="Path 395" d="M333.622,334.784l-5.485-8.977a.175.175,0,0,0-.161-.107.179.179,0,0,0-.126.053.161.161,0,0,0-.026.036l-5.359,8.983a.181.181,0,0,0,0,.192.174.174,0,0,0,.16.075h10.817a.173.173,0,0,0,.173-.077A.175.175,0,0,0,333.622,334.784Zm-5.164-.837a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-.5a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Zm0-1.763a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-2.876a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Z" transform="translate(-210.509 -318.31)" fill="#ed1156"/> </g> </svg> </span> <span class="das-redacted-value"> [Not publishable] </span> </span>\t\t\t</div>\n </div>\n</section></section></section> <section data-cy="das-block" class="das-block LocalEffects "\n id="ec0b4704-b91a-41bc-ae72-db3b06740dc1"\n> <h3 class="das-block_label">\n Local effects\n </h3>\n <section data-cy="das-block" class="das-block LongTermNoStudy "\n id="210ec56c-4d2b-4238-b812-0eb5bfbdc3c2"\n> <h3 class="das-block_label">\n Long term exposure\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label HazardAssessment">\n\t\t\tHazard assessment conclusion\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">no hazard identified</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label MostSensitiveEndpoint das-empty-value">\n\t\t\tMost sensitive endpoint\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n <section data-cy="das-block" class="das-block DNMELInfoWithoutRTR das-block_empty"\n id="f5410989-c56f-4896-a72f-7d4341b772dd"\n> <h3 class="das-block_label">\n DNEL related information\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DerivationMethod das-empty-value">\n\t\t\tDNEL derivation method\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label AssessmentFactor das-empty-value">\n\t\t\tOverall assessment factor (AF)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DoseDescriptorStart das-empty-value">\n\t\t\tDose descriptor\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DoseResponseAF das-empty-value">\n\t\t\tAF for dose response relationship\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DoseResponseJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DiffInDurationAF das-empty-value">\n\t\t\tAF for differences in duration of exposure\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DiffInDurationJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label InterspeciesAF das-empty-value">\n\t\t\tAF for interspecies differences (allometric scaling)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label InterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesAF das-empty-value">\n\t\t\tAF for other interspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesAF das-empty-value">\n\t\t\tAF for intraspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DatabaseQualityAF das-empty-value">\n\t\t\tAF for the quality of the whole database\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DatabaseJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthUncertaintiesAF das-empty-value">\n\t\t\tAF for remaining uncertainties\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label OthUncertaintiesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n</section> <section data-cy="das-block" class="das-block ExplanationForHazardConclusion das-block_empty"\n id="f025584b-4460-4d36-b6d5-02604dce4d9e"\n> <h3 class="das-block_label">\n Explanation for hazard conclusion\n </h3>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label JustificationAndComments das-empty-value">\n\t\t\tExplanation for hazard conclusion\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> <span class="das-redacted-icon"> <svg xmlns="http://www.w3.org/2000/svg" width="15.233" height="15.431" viewBox="0 0 15.233 15.431"> <g id="conf_flag" transform="translate(-107.9 -1.299)"> <path id="Path_394" data-name="Path 394" d="M109.832,9.81a38.965,38.965,0,0,0,5-1.761.688.688,0,0,1,.691-.043.617.617,0,0,1,.218.345,1.692,1.692,0,0,0,.1.276l.007-.011s0,0,0,.006l1.363-2.285a.245.245,0,0,1,.214-.126.242.242,0,0,1,.227.152l1.878,3.076a9.2,9.2,0,0,0,1.579-.445.5.5,0,0,0,.325-.475l-.021-5.158a.507.507,0,0,0-.6-.5c-.869.156-2.34.336-2.34.336-1.891.263-2.691-.436-2.963-.777a.876.876,0,0,1-.109-.167c-.381-.753-1.8-.954-3.2-.956a21.453,21.453,0,0,0-2.661.184,1.457,1.457,0,0,0-.687-.158,1.7,1.7,0,0,0-.282.023c-.383.062-.665.252-.68.473h0V15.233l0,.006v.148a.545.545,0,0,0,.122.344l.454.556a.542.542,0,0,0,.858-.024l.392-.539a.54.54,0,0,0,.1-.319V10.158l0-.141V9.81Zm0-7.612c2.308,2.456.5,6.4,0,7.377Z" transform="translate(0 0)" fill="#ed1156"/> <path id="Path_395" data-name="Path 395" d="M333.622,334.784l-5.485-8.977a.175.175,0,0,0-.161-.107.179.179,0,0,0-.126.053.161.161,0,0,0-.026.036l-5.359,8.983a.181.181,0,0,0,0,.192.174.174,0,0,0,.16.075h10.817a.173.173,0,0,0,.173-.077A.175.175,0,0,0,333.622,334.784Zm-5.164-.837a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-.5a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Zm0-1.763a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-2.876a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Z" transform="translate(-210.509 -318.31)" fill="#ed1156"/> </g> </svg> </span> <span class="das-redacted-value"> [Not publishable] </span> </span>\t\t\t</div>\n </div>\n</section></section> <section data-cy="das-block" class="das-block AcuteShortTermExposureStudy "\n id="afbb0a34-9870-41f3-8ed3-c9c217c30b64"\n> <h3 class="das-block_label">\n Acute/short term exposure\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label HazardAssessment">\n\t\t\tHazard assessment conclusion\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">no hazard identified</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label MostSensitiveEndpoint das-empty-value">\n\t\t\tMost sensitive endpoint\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n <section data-cy="das-block" class="das-block DNELInfoWithoutRouteToRouteWithoutExtrapolation das-block_empty"\n id="aa6616dc-58ba-4296-9f95-0005dae2a815"\n> <h3 class="das-block_label">\n DNEL related information\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DerivationMethod das-empty-value">\n\t\t\tDNEL derivation method\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OverallAssessmentFactor das-empty-value">\n\t\t\tOverall assessment factor (AF)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DoseDescriptorStart das-empty-value">\n\t\t\tDose descriptor starting point\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DoseResponseAF das-empty-value">\n\t\t\tAF for dose response relationship\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DoseResponseJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label InterspeciesAF das-empty-value">\n\t\t\tAF for interspecies differences (allometric scaling)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label InterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesAF das-empty-value">\n\t\t\tAF for other interspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesAF das-empty-value">\n\t\t\tAF for intraspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesJustifAF das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DatabaseQualityDatabaseQualityAF das-empty-value">\n\t\t\tAF for the quality of the whole database\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DatabaseQualityJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthUncertaintiesAF das-empty-value">\n\t\t\tAF for remaining uncertainties\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label UncertaintiesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n</section> <section data-cy="das-block" class="das-block ExplanationForHazardConclusion das-block_empty"\n id="f90e85e3-d0bd-44bf-923c-71f695c27f65"\n> <h3 class="das-block_label">\n Explanation for hazard conclusion\n </h3>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label JustificationAndComments das-empty-value">\n\t\t\tExplanation for hazard conclusion\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> <span class="das-redacted-icon"> <svg xmlns="http://www.w3.org/2000/svg" width="15.233" height="15.431" viewBox="0 0 15.233 15.431"> <g id="conf_flag" transform="translate(-107.9 -1.299)"> <path id="Path_394" data-name="Path 394" d="M109.832,9.81a38.965,38.965,0,0,0,5-1.761.688.688,0,0,1,.691-.043.617.617,0,0,1,.218.345,1.692,1.692,0,0,0,.1.276l.007-.011s0,0,0,.006l1.363-2.285a.245.245,0,0,1,.214-.126.242.242,0,0,1,.227.152l1.878,3.076a9.2,9.2,0,0,0,1.579-.445.5.5,0,0,0,.325-.475l-.021-5.158a.507.507,0,0,0-.6-.5c-.869.156-2.34.336-2.34.336-1.891.263-2.691-.436-2.963-.777a.876.876,0,0,1-.109-.167c-.381-.753-1.8-.954-3.2-.956a21.453,21.453,0,0,0-2.661.184,1.457,1.457,0,0,0-.687-.158,1.7,1.7,0,0,0-.282.023c-.383.062-.665.252-.68.473h0V15.233l0,.006v.148a.545.545,0,0,0,.122.344l.454.556a.542.542,0,0,0,.858-.024l.392-.539a.54.54,0,0,0,.1-.319V10.158l0-.141V9.81Zm0-7.612c2.308,2.456.5,6.4,0,7.377Z" transform="translate(0 0)" fill="#ed1156"/> <path id="Path_395" data-name="Path 395" d="M333.622,334.784l-5.485-8.977a.175.175,0,0,0-.161-.107.179.179,0,0,0-.126.053.161.161,0,0,0-.026.036l-5.359,8.983a.181.181,0,0,0,0,.192.174.174,0,0,0,.16.075h10.817a.173.173,0,0,0,.173-.077A.175.175,0,0,0,333.622,334.784Zm-5.164-.837a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-.5a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Zm0-1.763a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-2.876a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Z" transform="translate(-210.509 -318.31)" fill="#ed1156"/> </g> </svg> </span> <span class="das-redacted-value"> [Not publishable] </span> </span>\t\t\t</div>\n </div>\n</section></section></section></section> <section data-cy="das-block" class="das-block WorkersHazardForTheEyes "\n id="3f08da91-b6bc-47a7-b2d9-c72bc7102480"\n> <h3 class="das-block_label">\n Workers - Hazard for the eyes\n </h3>\n <section data-cy="das-block" class="das-block EyesLocalEffects "\n id="e16288a4-2e8e-4335-95fc-87abbe8468a9"\n> <h3 class="das-block_label">\n Local effects\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label Conclusion">\n\t\t\tHazard assessment conclusion\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">low hazard (no threshold derived)</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label Comments das-empty-value">\n\t\t\tExplanation for hazard conclusion\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> <span class="das-redacted-icon"> <svg xmlns="http://www.w3.org/2000/svg" width="15.233" height="15.431" viewBox="0 0 15.233 15.431"> <g id="conf_flag" transform="translate(-107.9 -1.299)"> <path id="Path_394" data-name="Path 394" d="M109.832,9.81a38.965,38.965,0,0,0,5-1.761.688.688,0,0,1,.691-.043.617.617,0,0,1,.218.345,1.692,1.692,0,0,0,.1.276l.007-.011s0,0,0,.006l1.363-2.285a.245.245,0,0,1,.214-.126.242.242,0,0,1,.227.152l1.878,3.076a9.2,9.2,0,0,0,1.579-.445.5.5,0,0,0,.325-.475l-.021-5.158a.507.507,0,0,0-.6-.5c-.869.156-2.34.336-2.34.336-1.891.263-2.691-.436-2.963-.777a.876.876,0,0,1-.109-.167c-.381-.753-1.8-.954-3.2-.956a21.453,21.453,0,0,0-2.661.184,1.457,1.457,0,0,0-.687-.158,1.7,1.7,0,0,0-.282.023c-.383.062-.665.252-.68.473h0V15.233l0,.006v.148a.545.545,0,0,0,.122.344l.454.556a.542.542,0,0,0,.858-.024l.392-.539a.54.54,0,0,0,.1-.319V10.158l0-.141V9.81Zm0-7.612c2.308,2.456.5,6.4,0,7.377Z" transform="translate(0 0)" fill="#ed1156"/> <path id="Path_395" data-name="Path 395" d="M333.622,334.784l-5.485-8.977a.175.175,0,0,0-.161-.107.179.179,0,0,0-.126.053.161.161,0,0,0-.026.036l-5.359,8.983a.181.181,0,0,0,0,.192.174.174,0,0,0,.16.075h10.817a.173.173,0,0,0,.173-.077A.175.175,0,0,0,333.622,334.784Zm-5.164-.837a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-.5a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Zm0-1.763a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-2.876a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Z" transform="translate(-210.509 -318.31)" fill="#ed1156"/> </g> </svg> </span> <span class="das-redacted-value"> [Not publishable] </span> </span>\t\t\t</div>\n </div>\n</section></section> <section data-cy="das-block" class="das-block AdditionalInformationWorkers "\n id="59eca627-93e1-41b8-94bb-e4c7591cbbb9"\n> <h3 class="das-block_label">\n Additional information - workers\n </h3>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text">\n\t\t<div class="das-field_label DiscussionWorkers das-empty-label">\n\t\t\t\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<p style="margin-bottom:0;top:0;line-height:150%;margin-top:0;"> <span style="font-family:Arial;font-size:10.0pt;">B.5.11.3 Worker-DNEL short-term inhalation route</span> </p> <p style="margin-bottom:0;top:0;margin-top:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="margin-bottom:0;top:0;margin-top:0;"> <span style="font-family:Arial;font-size:10.0pt;">Peak airborne exposure to ethylbenzene vapour may cause local respiratory irritation.</span> </p> <p style="margin-bottom:0;top:0;margin-top:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="margin-bottom:0;top:0;margin-top:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="margin-bottom:0;top:0;margin-top:0;"> <span style="font-family:Arial;font-size:10.0pt;">B.5.11.3.1 DNEL based on local respiratory irritation</span> </p> <p style="margin-bottom:0;top:0;margin-top:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="margin-bottom:0;top:0;margin-top:0;"> <span style="font-family:Arial;font-size:10.0pt;">The dose descriptor is obtained from a study on 12 normal human volunteers exposed for 4 h to fluctuating concentrations of ethylbenzene. The exposure consisted of 8 peaks of 200 ppm separated by troughs of 10 ppm with an integrated mean of 98 ppm. No significant difference was found when comparing the reporting of subjective nasal irritation under these conditions with that at a constant exposure to 10 ppm. Similarly, inflammatory biomarkers in nasal secretion were not affected under these exposure conditions. In addition 12 volunteers with self-reported Multiple Chemical Sensitivity (sMCS) were investigated. Nasal irritation reported by the sMCS subjects was again not significantly increased when comparing the fluctuating exposure condition against constant exposure at 10 ppm. But reported irritation was significantly higher in sMCS subjects in comparison to the normal subjects under the high exposure conditions (van Thriel et al., 2003).</span> </p> <p style="margin-bottom:0;top:0;margin-top:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="margin-bottom:0;top:0;margin-top:0;"> <span style="font-family:Arial;font-size:10.0pt;">Thus the dose descriptor is the NOAEC of 98 ppm for 4 h of exposure and 200 ppm for short term exposures of 15 min. Irritation is a concentration specific effect, it is therefore not necessary to modify the dose descriptor to take account of differences in breathing rates between volunteers at rest and active workers. The starting point is therefore 200 ppm for short term exposures and 98 ppm of a prolonged duration up to several hours for the normal worker population. It is pointed out that this starting point will lead to a very conservative DNEL since the NOAEC is the highest concentration investigated. The \xe2\x80\x9ctrue\xe2\x80\x9d NOAEC is not known but certainly is higher.</span> </p> <p style="margin-bottom:0;top:0;margin-top:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="margin-bottom:0;top:0;margin-top:0;"> <span style="font-family:Arial;font-size:10.0pt;">There is a further aspect strongly indicating that the NOAEC of 98 ppm for local respiratory irritation is highly conservative: after short term exposure of volunteers (one sniff from a squeeze bottle) the odour detection threshold was in the range of 20 ppm with a broad individual variation. In contrast, anosmics that will only react to (true) trigeminal irritation reported a nasal pungency threshold of 10100 ppm (Cometto-Muniz, 1994). As in the study of van Thriel et al. (2003) subjective reporting was the endpoint recorded, this subjective reporting may not represent true sensory irritation but may be confounded by olfaction. (Problems associated with defining the threshold for olfaction are demonstrated by the recent study of Cometto-Muniz and Abraham (2009). With a more sensitive approach as compared to the 1994-study, the odour threshold for alkylbenzenes decreased by several orders of magnitude being 6 ppb for ethylbenzene.)</span> </p> <p style="margin-bottom:0;top:0;margin-top:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <span style="font-family:Arial;font-size:10.0pt;"><br /> Table B.1: Assessment factors and DNEL calculation for worker-DNEL short-term inhalation local effects </span> <table border="1" style="border:none;" cellpadding="0" cellspacing="0"> <tr> <td style="border:solid windowtext 1.0pt;padding-top:0in;width:89.45pt;top:0in;padding-bottom:0in;padding-right:5.4pt;left:5.4pt;padding-left:5.4pt;" valign="top" width="119"><p style="margin-bottom:0;top:0;margin-top:0;"><span style="font-size:10.0pt;font-family:Arial;">Uncertainties</span></p></td> <td style="border:solid windowtext 1.0pt;left:none;padding-bottom:0in;top:0in;padding-left:5.4pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;" valign="top" width="56"><p style="margin-bottom:0;top:0;margin-top:0;"><span style="font-family:Arial;font-size:10.0pt;">AF</span></p></td> <td style="border:solid windowtext 1.0pt;left:none;padding-bottom:0in;top:0in;padding-left:5.4pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;" valign="top" width="393"><p style="margin-bottom:0;top:0;margin-top:0;"><span style="font-family:Arial;font-size:10.0pt;">Justification</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="margin-bottom:0;top:0;margin-top:0;"><span style="font-family:Arial;font-size:10.0pt;">Interspecies differences</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="margin-bottom:0;top:0;margin-top:0;"><span style="font-family:Arial;font-size:10.0pt;">-</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="margin-bottom:0;top:0;margin-top:0;"><span style="font-family:Arial;font-size:10.0pt;">The starting point is obtained from human data so it is not necessary to apply a factor to take account of interspecies differences.</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Intraspecies differences</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">3</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial">There are no data to quantify variability in susceptibility to the irritant effects of ethylbenzene in the human population. Since irritant effects relate to the concentration at the target site it is not necessary to apply a factor to take account of toxicokinetic differences. For workers REACH (2008) proposes an assessment factor of 5. However, following a review of data on respiratory irritants in human volunteers, ECETOC (2003. 2010) concluded that variations between individuals were small. In addition, the population exposed in the workplace is highly homogeneous and the health of the work force is typically good (healthy worker effect). The analysis of assessment factors conducted by ECETOC also showed that estimates of the upper 95th percentile of the distribution of variability in toxicokinetic and toxicodynamic parameters for populations of different ages, genders and disease states supports use of an assessment factor of 3 to account for intraspecies variability within workers.</font></p><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial"></font></p><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial">The factor of 3 proposed by ECETOC will be used for this study in humans.</font></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Differences in duration of exposure</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">It is not necessary to apply a factor to take account of duration of exposure.</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Dose response and endpoint specific/severity issues</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">The starting point is a NOAEC. In this study, normal volunteers exposed to 200 ppm for short term exposure peaks and to 98 ppm for 4 h did not report irritation. In contrast, slight irritation was reported by a selected group of sMCS persons with a high subjective sensitivity.</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Quality of database</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">The quality of the database for this endpoint is adequate and the study was conducted to modern standards. It is therefore not necessary to apply a factor to take account of deficiencies in the quality of the data.</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:426.1pt;padding-right:5.4pt;padding-top:0in;border-top:none;" colspan="3" valign="top" width="568"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Overall assessment factor:</span><span> </span><span style="font-family:Arial;font-size:10.0pt;">3</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:426.1pt;padding-right:5.4pt;padding-top:0in;border-top:none;" colspan="3" valign="top" width="568"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Endpoint specific DNEL:</span><span> </span><span style="font-family:Arial;font-size:10.0pt;">200/3 = 67 ppm for short term exposure peaks (15 min)</span></p><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Or 98/3 = 33 ppm for single exposures over several hours</span></p></td> </tr> </table> <p align="left" style="top:0;line-height:150%;margin-top:0;margin-bottom:0;"> </p> <p align="left" style="top:0;line-height:150%;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">B.5.11.3.2 Selection of worker-DNEL short-term inhalation</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">A DNEL of 67 ppm was calculated for respiratory tract irritation for short-term exposures of about 15 min. For single exposures of a few hours a DNEL of 33 ppm was derived.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">B.5.11.4 Worker-DNEL long-term inhalation route</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">For long-term repeated exposure the potential of ethylbenzene to induce ototoxicity and developmental toxicity should be discussed. For these endpoints the available human data do not provide sufficient information to allow a human dose descriptor to be identified. A dose descriptor for these endpoints can be identified from animal data. Since the dose-response relationship and evidence base for each endpoint is different it is not clear which is the critical endpoint for risk assessment of long-term repeated exposure. It will therefore be necessary to calculate separate endpoint specific DNELs for each effect to identify the critical long-term DNEL.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <span style="font-family:Arial;font-size:10.0pt;"><br /> </span> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">B.5.11.4.1 Endpoint specific DNEL for ototoxicity</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">Repeated inhalation exposure to ethylbenzene vapor was irreversibly ototoxic in rats (Gagnaire et al., 2007). Auditory dysfunction characterised by an elevation of hearing thresholds was localised in the mid frequencies and corresponded to the loss of cochlear outer hair cells, the sensory cells in the inner ear. Hearing loss and cell damage increased with exposure concentrations. In this 90 day rat inhalation study (6 hours/day, 6 day/week) the NOAEC for ototoxicity was extrapolated to be 114 ppm (500 mg/m\xc2\xb3) based on destruction of outer hair cells in row 3 occurring already at 200 ppm. In contrast, no effect on hearing ability as indicated by audiometric thresholds was observed at 200 ppm. According to several case reports where hearing deficits in humans occupationally exposed to organic solvents or from people after solvent abuse are described (for review cf Risk Assessment Reports on toluene and styrene), these rat data are taken to be relevant for humans.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">Thus, this extrapolated NOAEC of 114 ppm (500 mg/m\xc2\xb3) is taken as dose descriptor for DNEL derivation of repeated dose toxicity.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">The extrapolated NOAEC of 114 ppm (500 mg/m\xc2\xb3) from the rat is (1) multiplied with a factor of 0.45 (for rat absorption percentage of 45%), divided by a divisor of 0.65 (for human absorption percentage after inhalation of 65%) and (2) multiplied by a factor of 6.7/10 for activity-driven differences of respiratory volumes in workers. Further differences regarding the experimental inhalation duration (6 hours/day, 6 days/week) and the working conditions (8 hours/day, 5 days/week) are not considered, because they roughly balance each other.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">The calculation results in an adjusted inhalation starting point of 232 mg/m\xc2\xb3 (500 x 0.45/0.65 x 6.7/10).</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">In the overall assessment it has also be taken into consideration that the starting point to define ototoxicity is not auditory dysfunction but histopathological effects on the outer hair cells of the cochlea. Numerous investigations have shown that audiometric hearing deficits occur at higher exposure concentrations than (small) losses of hair cells in the outer row 3 of the cochlea. While the audiometric effects define the impact of ototoxicity for workers, the use of histopathological effects for the starting point implies a further conservative factor.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">Hearing loss is not a specific effect for ethylbenzene but has also been found with other aromatic solvents like styrene, toluene, or xylenes. Detailed mechanistic studies, especially with styrene, have demonstrated that ototoxicity is exerted by the unmetabolized parent chemical. Studies in rats with styrene and toluene showed that hearing loss occurs within a few days of the start of exposure and although it does not increase in severity with prolongation of exposure, the initial effect is irreversible. According to Gangnaire et al. (2007) ethylbenzene led to maximal hearing impairment after about 4 weeks without further deterioration by prolongation of exposure.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <span style="font-family:Arial;font-size:10.0pt;">Table B.2: Assessment factors and DNEL calculation for worker DNEL long-term inhalation for ototoxicity </span> <table border="1" style="border:none;" cellpadding="0" cellspacing="0"> <tr> <td style="border:solid windowtext 1.0pt;padding-top:0in;width:89.45pt;top:0in;padding-bottom:0in;left:5.4pt;padding-right:5.4pt;padding-left:5.4pt;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Uncertainties</span></p></td> <td style="border:solid windowtext 1.0pt;left:none;padding-bottom:0in;top:0in;padding-left:5.4pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">AF</span></p></td> <td style="border:solid windowtext 1.0pt;left:none;padding-bottom:0in;top:0in;padding-left:5.4pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Justification</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Interspecies differences</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">For interspecies variability the assessment factors proposed by ECETOC (2003, 2010) are used. The dose descriptor was obtained from an inhalation study and is being used to derive an inhalation DNEL. It is therefore not necessary to apply an allometric scaling factor to take account of differences in basal metabolic rates between animals and humans. According to ECETOC the additional assessment factor of 2.5 to quantify other differences between animals and humans that could affect interspecies extrapolation is scientifically not justified and a factor of 1 is appropriate. On this basis the default factor of 1 to account for other species differences will be applied.</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Intraspecies differences</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">3</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><font size="2" face="Arial">There are no data to quantify variability in susceptibility to the effects of long-term exposure to ethylbenzene in the human population. However the population exposed in the workplace is highly homogeneous and the health of the work force is typically good (healthy worker effect) while metabolic differences due to genetic polymorphisms do not automatically require an increased assessment factor since alternative pathways of elimination are often present (ECETOC, 2003, 2010). The analysis of assessment factors conducted by ECETOC also showed that estimates of the upper 95th percentile of the distribution of variability in toxicokinetic and toxicodynamic parameters for populations of different ages, genders and disease states supports use of an assessment factor of 3 to account for intraspecies variability within workers.</font><font size="2" face="Arial"></font><font size="2" face="Arial">The default factor of 3 for workers as proposed by ECETOC will therefore be used to take account of intraspecies variability.</font><font size="2" face="Arial">In total there is a combined inter- and intraspecies assessment factor of 3 that takes into account that the target tissue (outer hair cells in the cochlea, anatomical structure and blood supply of the cochlea) is identical in rats and humans. Furthermore, not hearing deficits but histopatological alterations of the cochlea were used as starting point. As histopathology is more sensitive than the physiological effects this is a conservative starting point per se.</font></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Differences in duration of exposure</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">The dose descriptor was obtained from a 90-day inhalation study. Although the DNEL is to be used to assess long-term repeated exposure there is strong evidence showing that the ototoxic effects of ethylbenzene have already occurred within the first four weeks of initial exposure and did not progress in severity with further exposure. On this basis, the duration of this study is adequate for the endpoint being studied and it is not necessary to apply a factor to take account of differences in duration of exposure.</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Dose response and endpoint specific/severity issues</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">As an extrapolated NOAEC for the most sensitive endpoint, i.e. histopathological alterations of cochlear hair cells, was used an additional assessment factor is not warranted. The study encompassed a range of concentrations and durations of exposure and provided reliable information on the dose-response relationship and severity of effect.</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Quality of database</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">The findings from the key study are supported by findings from several additional studies with similar aromatic solvents conducted to modern regulatory standards by separate groups of researchers. Therefore it is not necessary to apply an additional factor.</span><span>  </span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:426.1pt;padding-right:5.4pt;padding-top:0in;border-top:none;" colspan="3" valign="top" width="568"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Overall assessment factor:</span><span>  </span><span style="font-family:Arial;font-size:10.0pt;">3</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:426.1pt;padding-right:5.4pt;padding-top:0in;border-top:none;" colspan="3" valign="top" width="568"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Endpoint specific DNEL:</span><span> </span><span style="font-family:Arial;font-size:10.0pt;">232/3 = 77 mg/m\xc2\xb3 (8-hours) corresponding to 17.5 ppm</span></p></td> </tr> </table> <p align="left" style="top:0;line-height:150%;margin-top:0;margin-bottom:0;"> </p> <p align="left" style="top:0;line-height:150%;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">B.5.11.4.2 Endpoint specific DNEL for developmental toxicity</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">For DNEL derivation with regard to developmental toxicity two study types can be taken into consideration: (multi) generation and prenatal toxicity studies.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">B.5.11.4.2a DNEL based on (multi) generation studies</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">For definition of a DNEL two studies are available: A guideline 2-generation study with an indication of slight foetotoxicity (reduced foetal body weight and occasional increases in skeletal variations) in the presence of maternal toxicity with a NOAEC for foetal and maternal toxicity of 500 ppm and a preceding probe 1-generation reproduction toxicity study with a NOAEC of 100 ppm based on increased postnatal mortality and body weight gain depression in the offspring. As a general strategy, the guideline 2-generation study with a large number of experimental animals should have precedent over the probe study with a more limited number of animals. Furthermore, the specific life stages relevant for derivation of a DNEL long-tem for workers have to be defined.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">While exposure during pregnancy and lactation (via the milk) might occur in female workers under rare circumstances (e.g. if maternity leave is not taken), it is not possible that inhalation exposure at the workplace will occur in humans directly after weaning. Therefore, only effects found in offspring until the date of weaning should be taken into consideration to derive a long-term DNEL for workers, but not effects occurring in the offspring exposed by direct inhalation after weaning. A detailed evaluation of the probe 1-generation study leads to a NOAEC for the offspring until weaning of 500 ppm including body weight development and postnatal mortality. This corresponds to the NOAEC of the guideline 2-generation study.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">The NOAEC for developmental effects relevant for the exposure situation at the workplace is 500 ppm with an exposure schedule of 6h/d, 7 d/week. Transformation to the workplace situation (8h/d; 5d/week) would lead to 525 ppm (500 x 6/8 x 7/5), corresponding to 2300 mg/m\xc2\xb3. This NOAEC from the rat is (1) multiplied with a factor of 0.45 (for rat absorption percentage of 45 %) and divided by 0.65 (for human absorption percentage of 65 %) and (2) multiplied by a factor of 0.67 for activity differences of respiratory volumes in workers.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">The adjusted starting point is therefore 1070 mg/m\xc2\xb3.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <span style="font-family:Arial;font-size:10.0pt;"><br /> Table B.3: Assessment factors and DNEL calculation for worker DNEL long-term inhalation for developmental toxicity (generation studies)</span> <p align="left" style="top:0;line-height:150%;margin-top:0;margin-bottom:0;"> </p> <p align="left" style="top:0;line-height:150%;margin-top:0;margin-bottom:0;"> </p> <table border="1" style="border:none;" cellpadding="0" cellspacing="0"> <tr> <td style="border:solid windowtext 1.0pt;padding-top:0in;width:89.45pt;top:0in;padding-bottom:0in;left:5.4pt;padding-right:5.4pt;padding-left:5.4pt;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Uncertainties</span></p></td> <td style="border:solid windowtext 1.0pt;left:none;padding-bottom:0in;top:0in;padding-left:5.4pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">AF</span></p></td> <td style="border:solid windowtext 1.0pt;left:none;padding-bottom:0in;top:0in;padding-left:5.4pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Justification</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Interspecies differences</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">For interspecies variability the assessment factors proposed by ECETOC (2003, 2010) are used. The dose descriptor was obtained from an inhalation study and is being used to derive an inhalation DNEL. It is therefore not necessary to apply an allometric scaling factor to take account of differences in basal metabolic rates between animals and humans. According to ECETOC the additional assessment factor of 2.5 to quantify other differences between animals and humans that could affect interspecies extrapolation is scientifically not justified and a factor of 1 is appropriate. On this basis the default factor of 1 to account for other species differences will be applied.</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Intraspecies differences</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">3</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial">There are no data to quantify variability in susceptibility to the effects of long-term exposure to ethylbenzene in the human population. However the population exposed in the workplace is highly homogeneous and the health of the work force is typically good (healthy worker effect) while metabolic differences due to genetic polymorphisms do not automatically require an increased assessment factor since alternative pathways of elimination are often present (ECETOC, 2003, 2010). The analysis of assessment factors conducted by ECETOC also showed that estimates of the upper 95th percentile of the distribution of variability in toxicokinetic and toxicodynamic parameters for populations of different ages, genders and disease states supports use of an assessment factor of 3 to account for intraspecies variability within workers.</font></p><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial"></font></p><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial">The default factor of 3 for workers as proposed by ECETOC will therefore be used to take account of intraspecies variability.</font></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Differences in duration of exposure</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">The NOAEC was derived from the probe 1-generation and the 2-generation study starting from exposure of young adult animals of the F0 generation up to weaning of the F1 generation. This represents a worst case scenario for workers being exposed from the start of their working life, during pregnancy up to the end of the breast feeding period without maternity leave. An assessment factor of 1 is therefore appropriate.</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Dose response and endpoint specific/severity issues</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">As 500 ppm was a clear NOAEC for developmental effects in F1 offspring before weaning and start of direct inhalation exposure, an assessment factor is not warranted in this respect.</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Quality of database</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">The key study was conducted to modern regulatory standards and was adequately reported. On this basis the quality of the database is not considered to contribute uncertainty and it is therefore not necessary to apply an additional factor.</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:426.1pt;padding-right:5.4pt;padding-top:0in;border-top:none;" colspan="3" valign="top" width="568"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Overall assessment factor:</span><span>  </span><span style="font-family:Arial;font-size:10.0pt;">3</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:426.1pt;padding-right:5.4pt;padding-top:0in;border-top:none;" colspan="3" valign="top" width="568"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Endpoint specific DNEL:</span><span> </span><span style="font-family:Arial;font-size:10.0pt;">1070/3 = 357 mg/m\xc2\xb3 (8-hour) corresponding to 81 ppm</span></p></td> </tr> </table> <p align="left" style="top:0;line-height:150%;margin-top:0;margin-bottom:0;"> </p> <p align="left" style="top:0;line-height:150%;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">B.5.11.4.2b DNEL based on prenatal toxicity studies</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">The derivation of the DNEL is based on the prenatal toxicity study in rats of Saillenfait et al. (2003) at exposure concentrations of 100, 500, 1000, and 2000 ppm during gestation days 6-20 with a NOAEC of 500 ppm for an exposure regime of 6 h/d throughout gestation days 6-20.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">This NOAEC has to be adjusted by a factor of 6/8 to account for different daily exposure durations leading to 375 ppm. The dams were exposed every day during pregnancy and not at 5 d/week, as would have been workers. Due to the short duration of pregnancy in rats this fact is not taken into account by a factor of 7/5, leading to a more conservative DNEL derivation.The NOAEC of 375 ppm from the rat is (1) multiplied with a factor of 0.45 (for rat absorption percentage of 45 %) and divided by 0.65 (for human absorption percentage of 65 %) and (2) multiplied by a factor of 0.67 for activity differences of respiratory volumes in workers.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">The adjusted starting point is therefore 174 ppm.</span> </p> <span style="font-family:Arial;font-size:10.0pt;"><br /> Table B.4: Assessment factors and DNEL calculation for worker DNEL long-term inhalation for developmental toxicity (prenatal toxicity studies) </span> <table border="1" style="border:none;" cellpadding="0" cellspacing="0"> <tr> <td style="border:solid windowtext 1.0pt;padding-top:0in;width:89.45pt;top:0in;padding-bottom:0in;left:5.4pt;padding-right:5.4pt;padding-left:5.4pt;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Uncertainties</span></p></td> <td style="border:solid windowtext 1.0pt;left:none;padding-bottom:0in;top:0in;padding-left:5.4pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">AF</span></p></td> <td style="border:solid windowtext 1.0pt;left:none;padding-bottom:0in;top:0in;padding-left:5.4pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Justification</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Interspecies differences</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial">For interspecies variability the assessment factors proposed by ECETOC (2003, 2010) are used. The dose descriptor was obtained from an inhalation study and is being used to derive an inhalation DNEL. It is therefore not necessary to apply an allometric scaling factor to take account of differences in basal metabolic rates between animals and humans. According to ECETOC the additional assessment factor of 2.5 to quantify other differences between animals and humans that could affect interspecies extrapolation is scientifically not justified and a factor of 1 is appropriate. On this basis the default factor of 1 to account for other species differences will be applied.</font></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Intraspecies differences</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">3</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial">There are no data to quantify variability in susceptibility to the effects of long-term exposure to ethylbenzene in the human population. However the population exposed in the workplace is highly homogeneous and the health of the work force is typically good (healthy worker effect) while metabolic differences due to genetic polymorphisms do not automatically require an increased assessment factor since alternative pathways of elimination are often present (ECETOC, 2003, 2010). The analysis of assessment factors conducted by ECETOC also showed that estimates of the upper 95th percentile of the distribution of variability in toxicokinetic and toxicodynamic parameters for populations of different ages, genders and disease states supports use of an assessment factor of 3 to account for intraspecies variability within workers. </font></p><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial"></font></p><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial">The default factor of 3 for workers as proposed by ECETOC will therefore be used to take account of intraspecies variability.</font></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Differences in duration of exposure</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">The NOAEC was derived from a prenatal toxicity study with an exposure regime from gestation day 6 up to the end of pregnancy at gestation day 20. An assessment factor of 1 is therefore appropriate.</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Dose response and endpoint specific/severity issues</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">As 500 ppm was a clear NOAEC for developmental effects, an assessment factor is not warranted in this respect.</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Quality of database</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">The key study was conducted to modern regulatory standards and was adequately reported. On this basis the quality of the database is not considered to contribute uncertainty and it is therefore not necessary to apply an additional factor.</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:426.1pt;padding-right:5.4pt;padding-top:0in;border-top:none;" colspan="3" valign="top" width="568"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Overall assessment factor:</span><span>  </span><span style="font-family:Arial;font-size:10.0pt;">3</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:426.1pt;padding-right:5.4pt;padding-top:0in;border-top:none;" colspan="3" valign="top" width="568"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Endpoint specific DNEL:</span><span> </span><span style="font-family:Arial;font-size:10.0pt;">174/3 = 58 ppm (8-hour) corresponding to 255 mg/m\xc2\xb3</span></p></td> </tr> </table> <span style="font-family:Arial;font-size:10.0pt;">B.5.11.4.3 Selection of worker-DNEL long-term inhalation</span> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">The most sensitive endpoint-specific DNEL is that for ototoxicity. This endpoint is relevant for workers. So the endpoint specific DNEL for ototoxicity is identified as the worker-DNEL long-term inhalation.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">The worker DNEL long-term inhalation route is 17.5 ppm (8-hr TWA).</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">B.5.11.5 Worker-DNEL long-term dermal route</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">No information is available for systemic toxicity after repeated dermal exposure. Therefore the extrapolated NOAEC of 114 ppm (500 mg/m\xc2\xb3) based on ototoxicity from the 90 day inhalation rat study is taken for the dermal route, ototoxicity being the critical health effect leading to the lowest worker-DNEL long-term by inhalation.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">Expressed as (external) dose the value of 500 mg/m\xc2\xb3 corresponds to 190 mg/kg/day (500 mg/m\xc2\xb3 x default respiratory volume for the rat for 8 hours of 0.38 m\xc2\xb3/kg). With a rat adsorption percentage of 45% after inhalation the internal starting point corresponds to 86 mg/kg/day (190 mg/kg/day x 0.45).</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">It is necessary to convert this internal inhalative dose to an equivalent external dermal dose. There are several studies investigating dermal penetration of ethylbenzene but most of them have severe deficits, either using preparations not relevant for the possible exposure scenarios of ethylbenzene or not allowing for evaporation after dermal contact. The OECD test guideline for skin absorption studies describes a device that should be used for volatile chemicals. Only Susten et al. (1990) used an experimental design similar to that described by OECD. With hairless mice they determined a dermal penetration rate of 3.61%. It is generally recognized that the skin barrier in hairless mice is less efficient than that of humans. Therefore a penetration rate of 4% as used in this calculation is on the conservative side.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">With a penetration rate of 4% the internal inhalation dose corresponds to an external dermal dose of</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">86 x 100/4 = 2150 mg/kg/d.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <span style="font-family:Arial;font-size:10.0pt;">Table B.5: Assessment factors and DNEL calculation for worker DNEL long-term dermal for ototoxicity</span> <p align="left" style="top:0;line-height:150%;margin-top:0;margin-bottom:0;"> </p> <table border="1" style="border:none;" cellpadding="0" cellspacing="0"> <tr> <td style="border:solid windowtext 1.0pt;padding-top:0in;width:89.45pt;top:0in;padding-bottom:0in;left:5.4pt;padding-right:5.4pt;padding-left:5.4pt;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Uncertainties</span></p></td> <td style="border:solid windowtext 1.0pt;left:none;padding-bottom:0in;top:0in;padding-left:5.4pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">AF</span></p></td> <td style="border:solid windowtext 1.0pt;left:none;padding-bottom:0in;top:0in;padding-left:5.4pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Justification</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Interspecies differences</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">4</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">For interspecies variability the assessment factors proposed by ECETOC (2003, 2010) are used. The starting point is derived from the internal rat dose in mg/kg/d. Therefore, the allometric scaling factor of 4 is used to take account of differences in basal metabolic rates between animals and humans. According to ECETOC the additional assessment factor of 2.5 to quantify other differences between animals and humans that could affect interspecies extrapolation is scientifically not justified and a factor of 1 is appropriate. On this basis the default factor of 1 to account for other species differences will be applied.</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Intraspecies differences</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">3</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial">There are no data to quantify variability in susceptibility to the effects of long-term exposure to ethylbenzene in the human population. However the population exposed in the workplace is highly homogeneous and the health of the work force is typically good (healthy worker effect) while metabolic differences due to genetic polymorphisms do not automatically require an increased assessment factor since alternative pathways of elimination are often present (ECETOC, 2003, 2010). The analysis of assessment factors conducted by ECETOC also showed that estimates of the upper 95th percentile of the distribution of variability in toxicokinetic and toxicodynamic parameters for populations of different ages, genders and disease states supports use of an assessment factor of 3 to account for intraspecies variability within workers.</font></p><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial"></font></p><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial">The default factor of 3 for workers as proposed by ECETOC will therefore be used to take account of intraspecies variability.</font></p><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial">In total there is a combined inter- and intraspecies assessment factor of 12 that takes into account that the target tissue (outer hair cells in the cochlea, anatomical structure and blood supply of the cochlea) is identical in rats and humans. Furthermore, not hearing deficits but histopatological alterations of the cochlea were used as starting point. As histopathology is more sensitive than the physiological effects this is a conservative starting point per se.</font></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Differences in duration of exposure</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">The dose descriptor was obtained from a 90-day inhalation study. Although the DNEL is to be used to assess long-term repeated exposure there is strong evidence showing that the ototoxic effects of ethylbenzene have already occurred within the first four weeks of initial exposure and did not progress in severity with further exposure. On this basis, the duration of this study is adequate for the endpoint being studied and it is not necessary to apply a factor to take account of differences in duration of exposure.</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Dose response and endpoint specific/severity issues</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">As an extrapolated NOAEC for the most sensitive endpoint, i.e. histopathological alterations of cochlear hair cells, was used an additional assessment factor is not warranted. The study encompassed a range of concentrations and durations of exposure and provided reliable information on the dose-response relationship and severity of effect.</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Quality of database</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">The findings from the key study are supported by findings from several additional studies with similar aromatic solvents conducted to modern regulatory standards by separate groups of researchers. Therefore it is not necessary to apply an additional factor.</span><span>  </span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:426.1pt;padding-right:5.4pt;padding-top:0in;border-top:none;" colspan="3" valign="top" width="568"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Overall assessment factor:</span><span>  </span><span style="font-family:Arial;font-size:10.0pt;">12</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:426.1pt;padding-right:5.4pt;padding-top:0in;border-top:none;" colspan="3" valign="top" width="568"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Endpoint specific DNEL:</span><span> </span><span style="font-family:Arial;font-size:10.0pt;">2150/12 = 180 mg/kg/d (8-hours) corresponding to 12500 mg/person/d</span></p></td> </tr> </table> <span style="font-family:Arial;font-size:10.0pt;">The worker DNEL long-term dermal route for systemic effects is 180 mg/kg/d. </span><span style="font-family:Arial;font-size:10.0pt;">As a skin irritation DNEL is not quantifiable from the data this DNEL does not address the potential for local irritation</span><span style="font-family:Arial;font-size:10.0pt;">.</span> <p style="top:0;line-height:150%;margin-top:0;margin-bottom:0;text-align:justify;"> </p> <p style="top:0;line-height:150%;margin-top:0;margin-bottom:0;text-align:justify;"> <span style="line-height:150%;font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;line-height:150%;margin-top:0;margin-bottom:0;text-align:justify;"> <span style="line-height:150%;font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;line-height:150%;margin-top:0;margin-bottom:0;text-align:justify;"> <span style="line-height:150%;font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;line-height:150%;margin-top:0;margin-bottom:0;text-align:justify;"> <span style="line-height:150%;font-family:Arial;font-size:10.0pt;"> </span> </p> <span style="line-height:150%;font-family:Arial;font-size:10.0pt;"><b><i><br /></i></b></span>\t\t\t</div>\n </div>\n</section> <section data-cy="das-block" class="das-block GeneralPopulationHazardViaInhalationRoute "\n id="7df11fb3-dd46-4370-a179-8891267ada3b"\n> <h3 class="das-block_label">\n General Population - Hazard via inhalation route\n </h3>\n <section data-cy="das-block" class="das-block SystemicEffects "\n id="0838b00f-cfd5-477f-bf1e-deee503878da"\n> <h3 class="das-block_label">\n Systemic effects\n </h3>\n <section data-cy="das-block" class="das-block LongTermStudy "\n id="457beae2-41e7-4403-919e-c53c4f793912"\n> <h3 class="das-block_label">\n Long term exposure\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label HazardAssessment">\n\t\t\tHazard assessment conclusion\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">DNEL (Derived No Effect Level)</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity ">\n\t\t<div class="das-field_label StDose">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value">15</span>\t\t<span class="unit">\n\t\t\t <span class="phrase ">mg/m\xc2\xb3</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label MostSensitiveEndpoint">\n\t\t\tMost sensitive endpoint\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">repeated dose toxicity</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label OriginalStudy das-empty-value">\n\t\t\tRoute of original study\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n <section data-cy="das-block" class="das-block DNMELInfoWithRTR "\n id="e43bd61f-2544-42ed-9ab7-4e4b15747720"\n> <h3 class="das-block_label">\n DNEL related information\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DerivationMethod das-empty-value">\n\t\t\tDNEL derivation method\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal ">\n\t\t<div class="das-field_label AssessmentFactor">\n\t\t\tOverall assessment factor (AF)\n\t\t</div>\n <div class="das-field_value">\n5 </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DoseDescriptorStartingPoint das-empty-value">\n\t\t\tDose descriptor starting point\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label DoseDescriptorStartRTR">\n\t\t\tModified dose descriptor starting point\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">NOAEC</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDoseRTR das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label JustificationRTR das-empty-value">\n\t\t\tExplanation for the modification of the dose descriptor starting point\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> [Empty] </span>\t\t\t</div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DoseResponseAF das-empty-value">\n\t\t\tAF for dose response relationship\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DoseResponseJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DiffInDurationAF das-empty-value">\n\t\t\tAF for differences in duration of exposure\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DiffInDurationJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label InterspeciesAF das-empty-value">\n\t\t\tAF for interspecies differences (allometric scaling)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label InterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesAF das-empty-value">\n\t\t\tAF for other interspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesAF das-empty-value">\n\t\t\tAF for intraspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DatabaseQualityAF das-empty-value">\n\t\t\tAF for the quality of the whole database\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DatabaseJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthUncertaintiesAF das-empty-value">\n\t\t\tAF for remaining uncertainties\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label OthUncertaintiesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n</section> <section data-cy="das-block" class="das-block ExplanationForHazardConclusion das-block_empty"\n id="3d8e9aec-2b1a-482a-b18b-2dd1b7e19670"\n> <h3 class="das-block_label">\n Explanation for hazard conclusion\n </h3>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label JustificationAndComments das-empty-value">\n\t\t\tExplanation for hazard conclusion\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> <span class="das-redacted-icon"> <svg xmlns="http://www.w3.org/2000/svg" width="15.233" height="15.431" viewBox="0 0 15.233 15.431"> <g id="conf_flag" transform="translate(-107.9 -1.299)"> <path id="Path_394" data-name="Path 394" 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d="M333.622,334.784l-5.485-8.977a.175.175,0,0,0-.161-.107.179.179,0,0,0-.126.053.161.161,0,0,0-.026.036l-5.359,8.983a.181.181,0,0,0,0,.192.174.174,0,0,0,.16.075h10.817a.173.173,0,0,0,.173-.077A.175.175,0,0,0,333.622,334.784Zm-5.164-.837a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-.5a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Zm0-1.763a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-2.876a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Z" transform="translate(-210.509 -318.31)" fill="#ed1156"/> </g> </svg> </span> <span class="das-redacted-value"> [Not publishable] </span> </span>\t\t\t</div>\n </div>\n</section></section> <section data-cy="das-block" class="das-block AcuteShortTermExposureStudy "\n id="65adf59f-29ea-48e9-aee9-efc9a0d2fc75"\n> <h3 class="das-block_label">\n Acute/short term exposure\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label HazardAssessment">\n\t\t\tHazard assessment conclusion\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">low hazard (no threshold derived)</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label MostSensitiveEndpoint das-empty-value">\n\t\t\tMost sensitive endpoint\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label OriginalStudy das-empty-value">\n\t\t\tRoute of original study\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n <section data-cy="das-block" class="das-block DNELInfoWithRouteToRouteWithExtrapolation "\n id="574c69e3-e00c-4035-bafb-2e820fb48344"\n> <h3 class="das-block_label">\n DNEL related information\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DerivationMethod das-empty-value">\n\t\t\tDNEL derivation method\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OverallAssessmentFactor das-empty-value">\n\t\t\tOverall assessment factor (AF)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n\t <div class="das-field das-field_checkbox">\n\t\t<div class="das-field_label Extrapolated">\n\t\t\tDNEL extrapolated from long term DNEL\n\t\t</div>\n <div class="das-field_value">\n <span data-cy="das-value_checkbox-unchecked" class="das-value_checkbox-unchecked"></span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DoseDescriptorStartingPoint das-empty-value">\n\t\t\tDose descriptor starting point\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DoseDescriptorStartRTR das-empty-value">\n\t\t\tModified dose descriptor starting point\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDoseRTR das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label DoseDescriptorJustificationRTR das-empty-value">\n\t\t\tExplanation for the modification of the dose descriptor starting point\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> [Empty] </span>\t\t\t</div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DoseResponseAF das-empty-value">\n\t\t\tAF for dose response relationship\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DoseResponseJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label InterspeciesAF das-empty-value">\n\t\t\tAF for interspecies differences (allometric scaling)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label InterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesAF das-empty-value">\n\t\t\tAF for other interspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesAF das-empty-value">\n\t\t\tAF for intraspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesJustifAF das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DatabaseQualityDatabaseQualityAF das-empty-value">\n\t\t\tAF for the quality of the whole database\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DatabaseQualityJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthUncertaintiesAF das-empty-value">\n\t\t\tAF for remaining uncertainties\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label UncertaintiesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n</section> <section data-cy="das-block" class="das-block ExplanationForHazardConclusion das-block_empty"\n id="74014343-9c0f-4f17-8871-0b7ea0887521"\n> <h3 class="das-block_label">\n Explanation for hazard conclusion\n </h3>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label JustificationAndComments das-empty-value">\n\t\t\tExplanation for hazard conclusion\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> <span class="das-redacted-icon"> <svg xmlns="http://www.w3.org/2000/svg" width="15.233" height="15.431" viewBox="0 0 15.233 15.431"> <g id="conf_flag" transform="translate(-107.9 -1.299)"> <path id="Path_394" data-name="Path 394" d="M109.832,9.81a38.965,38.965,0,0,0,5-1.761.688.688,0,0,1,.691-.043.617.617,0,0,1,.218.345,1.692,1.692,0,0,0,.1.276l.007-.011s0,0,0,.006l1.363-2.285a.245.245,0,0,1,.214-.126.242.242,0,0,1,.227.152l1.878,3.076a9.2,9.2,0,0,0,1.579-.445.5.5,0,0,0,.325-.475l-.021-5.158a.507.507,0,0,0-.6-.5c-.869.156-2.34.336-2.34.336-1.891.263-2.691-.436-2.963-.777a.876.876,0,0,1-.109-.167c-.381-.753-1.8-.954-3.2-.956a21.453,21.453,0,0,0-2.661.184,1.457,1.457,0,0,0-.687-.158,1.7,1.7,0,0,0-.282.023c-.383.062-.665.252-.68.473h0V15.233l0,.006v.148a.545.545,0,0,0,.122.344l.454.556a.542.542,0,0,0,.858-.024l.392-.539a.54.54,0,0,0,.1-.319V10.158l0-.141V9.81Zm0-7.612c2.308,2.456.5,6.4,0,7.377Z" transform="translate(0 0)" fill="#ed1156"/> <path id="Path_395" data-name="Path 395" d="M333.622,334.784l-5.485-8.977a.175.175,0,0,0-.161-.107.179.179,0,0,0-.126.053.161.161,0,0,0-.026.036l-5.359,8.983a.181.181,0,0,0,0,.192.174.174,0,0,0,.16.075h10.817a.173.173,0,0,0,.173-.077A.175.175,0,0,0,333.622,334.784Zm-5.164-.837a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-.5a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Zm0-1.763a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-2.876a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Z" transform="translate(-210.509 -318.31)" fill="#ed1156"/> </g> </svg> </span> <span class="das-redacted-value"> [Not publishable] </span> </span>\t\t\t</div>\n </div>\n</section></section></section> <section data-cy="das-block" class="das-block LocalEffects "\n id="8f04f719-3728-415a-9720-4fa159c5bf15"\n> <h3 class="das-block_label">\n Local effects\n </h3>\n <section data-cy="das-block" class="das-block LongTermNoStudy "\n id="bc92a6ac-918b-4030-b1a0-c2e529fb7063"\n> <h3 class="das-block_label">\n Long term exposure\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label HazardAssessment">\n\t\t\tHazard assessment conclusion\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">no hazard identified</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label MostSensitiveEndpoint das-empty-value">\n\t\t\tMost sensitive endpoint\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n <section data-cy="das-block" class="das-block DNMELInfoWithoutRTR das-block_empty"\n id="2a401cb8-462b-4694-8397-db2fcf7592b3"\n> <h3 class="das-block_label">\n DNEL related information\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DerivationMethod das-empty-value">\n\t\t\tDNEL derivation method\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label AssessmentFactor das-empty-value">\n\t\t\tOverall assessment factor (AF)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DoseDescriptorStart das-empty-value">\n\t\t\tDose descriptor\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DoseResponseAF das-empty-value">\n\t\t\tAF for dose response relationship\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DoseResponseJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DiffInDurationAF das-empty-value">\n\t\t\tAF for differences in duration of exposure\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DiffInDurationJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label InterspeciesAF das-empty-value">\n\t\t\tAF for interspecies differences (allometric scaling)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label InterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesAF das-empty-value">\n\t\t\tAF for other interspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesAF das-empty-value">\n\t\t\tAF for intraspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DatabaseQualityAF das-empty-value">\n\t\t\tAF for the quality of the whole database\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DatabaseJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthUncertaintiesAF das-empty-value">\n\t\t\tAF for remaining uncertainties\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label OthUncertaintiesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n</section> <section data-cy="das-block" class="das-block ExplanationForHazardConclusion das-block_empty"\n id="534a137c-e186-443f-bef4-7524a0f5c17f"\n> <h3 class="das-block_label">\n Explanation for hazard conclusion\n </h3>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label JustificationAndComments das-empty-value">\n\t\t\tExplanation for hazard conclusion\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> <span class="das-redacted-icon"> <svg xmlns="http://www.w3.org/2000/svg" width="15.233" height="15.431" viewBox="0 0 15.233 15.431"> <g id="conf_flag" transform="translate(-107.9 -1.299)"> <path id="Path_394" data-name="Path 394" d="M109.832,9.81a38.965,38.965,0,0,0,5-1.761.688.688,0,0,1,.691-.043.617.617,0,0,1,.218.345,1.692,1.692,0,0,0,.1.276l.007-.011s0,0,0,.006l1.363-2.285a.245.245,0,0,1,.214-.126.242.242,0,0,1,.227.152l1.878,3.076a9.2,9.2,0,0,0,1.579-.445.5.5,0,0,0,.325-.475l-.021-5.158a.507.507,0,0,0-.6-.5c-.869.156-2.34.336-2.34.336-1.891.263-2.691-.436-2.963-.777a.876.876,0,0,1-.109-.167c-.381-.753-1.8-.954-3.2-.956a21.453,21.453,0,0,0-2.661.184,1.457,1.457,0,0,0-.687-.158,1.7,1.7,0,0,0-.282.023c-.383.062-.665.252-.68.473h0V15.233l0,.006v.148a.545.545,0,0,0,.122.344l.454.556a.542.542,0,0,0,.858-.024l.392-.539a.54.54,0,0,0,.1-.319V10.158l0-.141V9.81Zm0-7.612c2.308,2.456.5,6.4,0,7.377Z" transform="translate(0 0)" fill="#ed1156"/> <path id="Path_395" data-name="Path 395" d="M333.622,334.784l-5.485-8.977a.175.175,0,0,0-.161-.107.179.179,0,0,0-.126.053.161.161,0,0,0-.026.036l-5.359,8.983a.181.181,0,0,0,0,.192.174.174,0,0,0,.16.075h10.817a.173.173,0,0,0,.173-.077A.175.175,0,0,0,333.622,334.784Zm-5.164-.837a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-.5a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Zm0-1.763a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-2.876a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Z" transform="translate(-210.509 -318.31)" fill="#ed1156"/> </g> </svg> </span> <span class="das-redacted-value"> [Not publishable] </span> </span>\t\t\t</div>\n </div>\n</section></section> <section data-cy="das-block" class="das-block AcuteShortTermExposureStudy "\n id="ecbf112d-a1a7-4907-8ea6-6dbdf3e97629"\n> <h3 class="das-block_label">\n Acute/short term exposure\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label HazardAssessment">\n\t\t\tHazard assessment conclusion\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">no hazard identified</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label MostSensitiveEndpoint das-empty-value">\n\t\t\tMost sensitive endpoint\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n <section data-cy="das-block" class="das-block DNELInfoWithoutRouteToRouteWithExtrapolation "\n id="746c658f-4ad2-49f4-a057-7508374d00f7"\n> <h3 class="das-block_label">\n DNEL related information\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DerivationMethod das-empty-value">\n\t\t\tDNEL derivation method\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OverallAssessmentFactor das-empty-value">\n\t\t\tOverall assessment factor (AF)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n\t <div class="das-field das-field_checkbox">\n\t\t<div class="das-field_label Extrapolated">\n\t\t\tDNEL extrapolated from long term DNEL\n\t\t</div>\n <div class="das-field_value">\n <span data-cy="das-value_checkbox-unchecked" class="das-value_checkbox-unchecked"></span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DoseDescriptorStart das-empty-value">\n\t\t\tDose descriptor starting point\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DoseResponseAF das-empty-value">\n\t\t\tAF for dose response relationship\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DoseResponseJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label InterspeciesAF das-empty-value">\n\t\t\tAF for interspecies differences (allometric scaling)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label InterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesAF das-empty-value">\n\t\t\tAF for other interspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesAF das-empty-value">\n\t\t\tAF for intraspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesJustifAF das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DatabaseQualityDatabaseQualityAF das-empty-value">\n\t\t\tAF for the quality of the whole database\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DatabaseQualityJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthUncertaintiesAF das-empty-value">\n\t\t\tAF for remaining uncertainties\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label UncertaintiesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n</section> <section data-cy="das-block" class="das-block ExplanationForHazardConclusion das-block_empty"\n id="f1dbf53f-7cca-4348-beed-9ffd56f4847e"\n> <h3 class="das-block_label">\n Explanation for hazard conclusion\n </h3>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label JustificationAndComments das-empty-value">\n\t\t\tExplanation for hazard conclusion\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> <span class="das-redacted-icon"> <svg xmlns="http://www.w3.org/2000/svg" width="15.233" height="15.431" viewBox="0 0 15.233 15.431"> <g id="conf_flag" transform="translate(-107.9 -1.299)"> <path id="Path_394" data-name="Path 394" d="M109.832,9.81a38.965,38.965,0,0,0,5-1.761.688.688,0,0,1,.691-.043.617.617,0,0,1,.218.345,1.692,1.692,0,0,0,.1.276l.007-.011s0,0,0,.006l1.363-2.285a.245.245,0,0,1,.214-.126.242.242,0,0,1,.227.152l1.878,3.076a9.2,9.2,0,0,0,1.579-.445.5.5,0,0,0,.325-.475l-.021-5.158a.507.507,0,0,0-.6-.5c-.869.156-2.34.336-2.34.336-1.891.263-2.691-.436-2.963-.777a.876.876,0,0,1-.109-.167c-.381-.753-1.8-.954-3.2-.956a21.453,21.453,0,0,0-2.661.184,1.457,1.457,0,0,0-.687-.158,1.7,1.7,0,0,0-.282.023c-.383.062-.665.252-.68.473h0V15.233l0,.006v.148a.545.545,0,0,0,.122.344l.454.556a.542.542,0,0,0,.858-.024l.392-.539a.54.54,0,0,0,.1-.319V10.158l0-.141V9.81Zm0-7.612c2.308,2.456.5,6.4,0,7.377Z" transform="translate(0 0)" fill="#ed1156"/> <path id="Path_395" data-name="Path 395" d="M333.622,334.784l-5.485-8.977a.175.175,0,0,0-.161-.107.179.179,0,0,0-.126.053.161.161,0,0,0-.026.036l-5.359,8.983a.181.181,0,0,0,0,.192.174.174,0,0,0,.16.075h10.817a.173.173,0,0,0,.173-.077A.175.175,0,0,0,333.622,334.784Zm-5.164-.837a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-.5a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Zm0-1.763a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-2.876a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Z" transform="translate(-210.509 -318.31)" fill="#ed1156"/> </g> </svg> </span> <span class="das-redacted-value"> [Not publishable] </span> </span>\t\t\t</div>\n </div>\n</section></section></section></section> <section data-cy="das-block" class="das-block GeneralPopulationHazardViaDermalRoute "\n id="491e3891-8daa-4df3-8700-4c6bc663dd92"\n> <h3 class="das-block_label">\n General Population - Hazard via dermal route\n </h3>\n <section data-cy="das-block" class="das-block SystemicEffects "\n id="c7b307d4-a160-4c8a-8b20-7f079831809b"\n> <h3 class="das-block_label">\n Systemic effects\n </h3>\n <section data-cy="das-block" class="das-block LongTermStudy "\n id="a4c085fc-743c-48a0-a148-78d97d351eea"\n> <h3 class="das-block_label">\n Long term exposure\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label HazardAssessment">\n\t\t\tHazard assessment conclusion\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">no hazard identified</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label MostSensitiveEndpoint das-empty-value">\n\t\t\tMost sensitive endpoint\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label OriginalStudy das-empty-value">\n\t\t\tRoute of original study\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n <section data-cy="das-block" class="das-block DNMELInfoWithRTR das-block_empty"\n id="5ffcefc2-7b0d-487c-9749-8d4a3734ea72"\n> <h3 class="das-block_label">\n DNEL related information\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DerivationMethod das-empty-value">\n\t\t\tDNEL derivation method\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label AssessmentFactor das-empty-value">\n\t\t\tOverall assessment factor (AF)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DoseDescriptorStartingPoint das-empty-value">\n\t\t\tDose descriptor starting point\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DoseDescriptorStartRTR das-empty-value">\n\t\t\tModified dose descriptor starting point\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDoseRTR das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label JustificationRTR das-empty-value">\n\t\t\tExplanation for the modification of the dose descriptor starting point\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> [Empty] </span>\t\t\t</div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DoseResponseAF das-empty-value">\n\t\t\tAF for dose response relationship\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DoseResponseJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DiffInDurationAF das-empty-value">\n\t\t\tAF for differences in duration of exposure\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DiffInDurationJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label InterspeciesAF das-empty-value">\n\t\t\tAF for interspecies differences (allometric scaling)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label InterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesAF das-empty-value">\n\t\t\tAF for other interspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesAF das-empty-value">\n\t\t\tAF for intraspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DatabaseQualityAF das-empty-value">\n\t\t\tAF for the quality of the whole database\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DatabaseJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthUncertaintiesAF das-empty-value">\n\t\t\tAF for remaining uncertainties\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label OthUncertaintiesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n</section> <section data-cy="das-block" class="das-block ExplanationForHazardConclusion das-block_empty"\n id="a19d25a5-9e8a-49a0-96c3-da5b8ab1ca0c"\n> <h3 class="das-block_label">\n Explanation for hazard conclusion\n </h3>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label JustificationAndComments das-empty-value">\n\t\t\tExplanation for hazard conclusion\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> <span class="das-redacted-icon"> <svg xmlns="http://www.w3.org/2000/svg" width="15.233" height="15.431" viewBox="0 0 15.233 15.431"> <g id="conf_flag" transform="translate(-107.9 -1.299)"> <path id="Path_394" data-name="Path 394" d="M109.832,9.81a38.965,38.965,0,0,0,5-1.761.688.688,0,0,1,.691-.043.617.617,0,0,1,.218.345,1.692,1.692,0,0,0,.1.276l.007-.011s0,0,0,.006l1.363-2.285a.245.245,0,0,1,.214-.126.242.242,0,0,1,.227.152l1.878,3.076a9.2,9.2,0,0,0,1.579-.445.5.5,0,0,0,.325-.475l-.021-5.158a.507.507,0,0,0-.6-.5c-.869.156-2.34.336-2.34.336-1.891.263-2.691-.436-2.963-.777a.876.876,0,0,1-.109-.167c-.381-.753-1.8-.954-3.2-.956a21.453,21.453,0,0,0-2.661.184,1.457,1.457,0,0,0-.687-.158,1.7,1.7,0,0,0-.282.023c-.383.062-.665.252-.68.473h0V15.233l0,.006v.148a.545.545,0,0,0,.122.344l.454.556a.542.542,0,0,0,.858-.024l.392-.539a.54.54,0,0,0,.1-.319V10.158l0-.141V9.81Zm0-7.612c2.308,2.456.5,6.4,0,7.377Z" transform="translate(0 0)" fill="#ed1156"/> <path id="Path_395" data-name="Path 395" d="M333.622,334.784l-5.485-8.977a.175.175,0,0,0-.161-.107.179.179,0,0,0-.126.053.161.161,0,0,0-.026.036l-5.359,8.983a.181.181,0,0,0,0,.192.174.174,0,0,0,.16.075h10.817a.173.173,0,0,0,.173-.077A.175.175,0,0,0,333.622,334.784Zm-5.164-.837a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-.5a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Zm0-1.763a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-2.876a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Z" transform="translate(-210.509 -318.31)" fill="#ed1156"/> </g> </svg> </span> <span class="das-redacted-value"> [Not publishable] </span> </span>\t\t\t</div>\n </div>\n</section></section> <section data-cy="das-block" class="das-block AcuteShortTermExposureStudy "\n id="847fa152-f0bb-4222-aeb2-4df402d00c7e"\n> <h3 class="das-block_label">\n Acute/short term exposure\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label HazardAssessment">\n\t\t\tHazard assessment conclusion\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">no hazard identified</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label MostSensitiveEndpoint das-empty-value">\n\t\t\tMost sensitive endpoint\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label OriginalStudy das-empty-value">\n\t\t\tRoute of original study\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n <section data-cy="das-block" class="das-block DNELInfoWithRouteToRouteWithExtrapolation "\n id="9243d46e-4a99-4340-b1f3-2b4ab9a8fb94"\n> <h3 class="das-block_label">\n DNEL related information\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DerivationMethod das-empty-value">\n\t\t\tDNEL derivation method\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OverallAssessmentFactor das-empty-value">\n\t\t\tOverall assessment factor (AF)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n\t <div class="das-field das-field_checkbox">\n\t\t<div class="das-field_label Extrapolated">\n\t\t\tDNEL extrapolated from long term DNEL\n\t\t</div>\n <div class="das-field_value">\n <span data-cy="das-value_checkbox-unchecked" class="das-value_checkbox-unchecked"></span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DoseDescriptorStartingPoint das-empty-value">\n\t\t\tDose descriptor starting point\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DoseDescriptorStartRTR das-empty-value">\n\t\t\tModified dose descriptor starting point\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDoseRTR das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label DoseDescriptorJustificationRTR das-empty-value">\n\t\t\tExplanation for the modification of the dose descriptor starting point\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> [Empty] </span>\t\t\t</div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DoseResponseAF das-empty-value">\n\t\t\tAF for dose response relationship\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DoseResponseJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label InterspeciesAF das-empty-value">\n\t\t\tAF for interspecies differences (allometric scaling)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label InterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesAF das-empty-value">\n\t\t\tAF for other interspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesAF das-empty-value">\n\t\t\tAF for intraspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesJustifAF das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DatabaseQualityDatabaseQualityAF das-empty-value">\n\t\t\tAF for the quality of the whole database\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DatabaseQualityJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthUncertaintiesAF das-empty-value">\n\t\t\tAF for remaining uncertainties\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label UncertaintiesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n</section> <section data-cy="das-block" class="das-block ExplanationForHazardConclusion das-block_empty"\n id="13f90aae-5845-4cb1-a6cb-a014ae669760"\n> <h3 class="das-block_label">\n Explanation for hazard conclusion\n </h3>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label JustificationAndComments das-empty-value">\n\t\t\tExplanation for hazard conclusion\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> <span class="das-redacted-icon"> <svg xmlns="http://www.w3.org/2000/svg" width="15.233" height="15.431" viewBox="0 0 15.233 15.431"> <g id="conf_flag" transform="translate(-107.9 -1.299)"> <path id="Path_394" data-name="Path 394" d="M109.832,9.81a38.965,38.965,0,0,0,5-1.761.688.688,0,0,1,.691-.043.617.617,0,0,1,.218.345,1.692,1.692,0,0,0,.1.276l.007-.011s0,0,0,.006l1.363-2.285a.245.245,0,0,1,.214-.126.242.242,0,0,1,.227.152l1.878,3.076a9.2,9.2,0,0,0,1.579-.445.5.5,0,0,0,.325-.475l-.021-5.158a.507.507,0,0,0-.6-.5c-.869.156-2.34.336-2.34.336-1.891.263-2.691-.436-2.963-.777a.876.876,0,0,1-.109-.167c-.381-.753-1.8-.954-3.2-.956a21.453,21.453,0,0,0-2.661.184,1.457,1.457,0,0,0-.687-.158,1.7,1.7,0,0,0-.282.023c-.383.062-.665.252-.68.473h0V15.233l0,.006v.148a.545.545,0,0,0,.122.344l.454.556a.542.542,0,0,0,.858-.024l.392-.539a.54.54,0,0,0,.1-.319V10.158l0-.141V9.81Zm0-7.612c2.308,2.456.5,6.4,0,7.377Z" transform="translate(0 0)" fill="#ed1156"/> <path id="Path_395" data-name="Path 395" d="M333.622,334.784l-5.485-8.977a.175.175,0,0,0-.161-.107.179.179,0,0,0-.126.053.161.161,0,0,0-.026.036l-5.359,8.983a.181.181,0,0,0,0,.192.174.174,0,0,0,.16.075h10.817a.173.173,0,0,0,.173-.077A.175.175,0,0,0,333.622,334.784Zm-5.164-.837a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-.5a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Zm0-1.763a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-2.876a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Z" transform="translate(-210.509 -318.31)" fill="#ed1156"/> </g> </svg> </span> <span class="das-redacted-value"> [Not publishable] </span> </span>\t\t\t</div>\n </div>\n</section></section></section> <section data-cy="das-block" class="das-block LocalEffects "\n id="a74df1f1-2b64-4ee8-9764-ea5d28075677"\n> <h3 class="das-block_label">\n Local effects\n </h3>\n <section data-cy="das-block" class="das-block LongTermNoStudy "\n id="949cf53e-95cf-48da-bc76-fd271a2d465a"\n> <h3 class="das-block_label">\n Long term exposure\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label HazardAssessment">\n\t\t\tHazard assessment conclusion\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">no hazard identified</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label MostSensitiveEndpoint das-empty-value">\n\t\t\tMost sensitive endpoint\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n <section data-cy="das-block" class="das-block DNMELInfoWithoutRTR das-block_empty"\n id="1c617d2e-a158-404f-bcc5-348606acefa2"\n> <h3 class="das-block_label">\n DNEL related information\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DerivationMethod das-empty-value">\n\t\t\tDNEL derivation method\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label AssessmentFactor das-empty-value">\n\t\t\tOverall assessment factor (AF)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DoseDescriptorStart das-empty-value">\n\t\t\tDose descriptor\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DoseResponseAF das-empty-value">\n\t\t\tAF for dose response relationship\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DoseResponseJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DiffInDurationAF das-empty-value">\n\t\t\tAF for differences in duration of exposure\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DiffInDurationJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label InterspeciesAF das-empty-value">\n\t\t\tAF for interspecies differences (allometric scaling)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label InterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesAF das-empty-value">\n\t\t\tAF for other interspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesAF das-empty-value">\n\t\t\tAF for intraspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DatabaseQualityAF das-empty-value">\n\t\t\tAF for the quality of the whole database\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DatabaseJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthUncertaintiesAF das-empty-value">\n\t\t\tAF for remaining uncertainties\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label OthUncertaintiesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n</section> <section data-cy="das-block" class="das-block ExplanationForHazardConclusion das-block_empty"\n id="2fe9615e-f51c-4195-8b2f-6a256f60559c"\n> <h3 class="das-block_label">\n Explanation for hazard conclusion\n </h3>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label JustificationAndComments das-empty-value">\n\t\t\tExplanation for hazard conclusion\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> <span class="das-redacted-icon"> <svg xmlns="http://www.w3.org/2000/svg" width="15.233" height="15.431" viewBox="0 0 15.233 15.431"> <g id="conf_flag" transform="translate(-107.9 -1.299)"> <path id="Path_394" data-name="Path 394" d="M109.832,9.81a38.965,38.965,0,0,0,5-1.761.688.688,0,0,1,.691-.043.617.617,0,0,1,.218.345,1.692,1.692,0,0,0,.1.276l.007-.011s0,0,0,.006l1.363-2.285a.245.245,0,0,1,.214-.126.242.242,0,0,1,.227.152l1.878,3.076a9.2,9.2,0,0,0,1.579-.445.5.5,0,0,0,.325-.475l-.021-5.158a.507.507,0,0,0-.6-.5c-.869.156-2.34.336-2.34.336-1.891.263-2.691-.436-2.963-.777a.876.876,0,0,1-.109-.167c-.381-.753-1.8-.954-3.2-.956a21.453,21.453,0,0,0-2.661.184,1.457,1.457,0,0,0-.687-.158,1.7,1.7,0,0,0-.282.023c-.383.062-.665.252-.68.473h0V15.233l0,.006v.148a.545.545,0,0,0,.122.344l.454.556a.542.542,0,0,0,.858-.024l.392-.539a.54.54,0,0,0,.1-.319V10.158l0-.141V9.81Zm0-7.612c2.308,2.456.5,6.4,0,7.377Z" transform="translate(0 0)" fill="#ed1156"/> <path id="Path_395" data-name="Path 395" d="M333.622,334.784l-5.485-8.977a.175.175,0,0,0-.161-.107.179.179,0,0,0-.126.053.161.161,0,0,0-.026.036l-5.359,8.983a.181.181,0,0,0,0,.192.174.174,0,0,0,.16.075h10.817a.173.173,0,0,0,.173-.077A.175.175,0,0,0,333.622,334.784Zm-5.164-.837a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-.5a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Zm0-1.763a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-2.876a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Z" transform="translate(-210.509 -318.31)" fill="#ed1156"/> </g> </svg> </span> <span class="das-redacted-value"> [Not publishable] </span> </span>\t\t\t</div>\n </div>\n</section></section> <section data-cy="das-block" class="das-block AcuteShortTermExposureStudy "\n id="e241facd-1e06-4274-b737-56feda7a050e"\n> <h3 class="das-block_label">\n Acute/short term exposure\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label HazardAssessment">\n\t\t\tHazard assessment conclusion\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">no hazard identified</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label MostSensitiveEndpoint das-empty-value">\n\t\t\tMost sensitive endpoint\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n <section data-cy="das-block" class="das-block DNELInfoWithoutRouteToRouteWithoutExtrapolation das-block_empty"\n id="a1c536bf-9dd1-4c7c-8c6c-20222fbdd80f"\n> <h3 class="das-block_label">\n DNEL related information\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DerivationMethod das-empty-value">\n\t\t\tDNEL derivation method\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OverallAssessmentFactor das-empty-value">\n\t\t\tOverall assessment factor (AF)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DoseDescriptorStart das-empty-value">\n\t\t\tDose descriptor starting point\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DoseResponseAF das-empty-value">\n\t\t\tAF for dose response relationship\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DoseResponseJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label InterspeciesAF das-empty-value">\n\t\t\tAF for interspecies differences (allometric scaling)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label InterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesAF das-empty-value">\n\t\t\tAF for other interspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesAF das-empty-value">\n\t\t\tAF for intraspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesJustifAF das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DatabaseQualityDatabaseQualityAF das-empty-value">\n\t\t\tAF for the quality of the whole database\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DatabaseQualityJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthUncertaintiesAF das-empty-value">\n\t\t\tAF for remaining uncertainties\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label UncertaintiesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n</section> <section data-cy="das-block" class="das-block ExplanationForHazardConclusion das-block_empty"\n id="4700ee35-f38a-435f-b0d1-8a93c02e04fb"\n> <h3 class="das-block_label">\n Explanation for hazard conclusion\n </h3>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label JustificationAndComments das-empty-value">\n\t\t\tExplanation for hazard conclusion\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> <span class="das-redacted-icon"> <svg xmlns="http://www.w3.org/2000/svg" width="15.233" height="15.431" viewBox="0 0 15.233 15.431"> <g id="conf_flag" transform="translate(-107.9 -1.299)"> <path id="Path_394" data-name="Path 394" d="M109.832,9.81a38.965,38.965,0,0,0,5-1.761.688.688,0,0,1,.691-.043.617.617,0,0,1,.218.345,1.692,1.692,0,0,0,.1.276l.007-.011s0,0,0,.006l1.363-2.285a.245.245,0,0,1,.214-.126.242.242,0,0,1,.227.152l1.878,3.076a9.2,9.2,0,0,0,1.579-.445.5.5,0,0,0,.325-.475l-.021-5.158a.507.507,0,0,0-.6-.5c-.869.156-2.34.336-2.34.336-1.891.263-2.691-.436-2.963-.777a.876.876,0,0,1-.109-.167c-.381-.753-1.8-.954-3.2-.956a21.453,21.453,0,0,0-2.661.184,1.457,1.457,0,0,0-.687-.158,1.7,1.7,0,0,0-.282.023c-.383.062-.665.252-.68.473h0V15.233l0,.006v.148a.545.545,0,0,0,.122.344l.454.556a.542.542,0,0,0,.858-.024l.392-.539a.54.54,0,0,0,.1-.319V10.158l0-.141V9.81Zm0-7.612c2.308,2.456.5,6.4,0,7.377Z" transform="translate(0 0)" fill="#ed1156"/> <path id="Path_395" data-name="Path 395" d="M333.622,334.784l-5.485-8.977a.175.175,0,0,0-.161-.107.179.179,0,0,0-.126.053.161.161,0,0,0-.026.036l-5.359,8.983a.181.181,0,0,0,0,.192.174.174,0,0,0,.16.075h10.817a.173.173,0,0,0,.173-.077A.175.175,0,0,0,333.622,334.784Zm-5.164-.837a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-.5a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Zm0-1.763a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-2.876a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Z" transform="translate(-210.509 -318.31)" fill="#ed1156"/> </g> </svg> </span> <span class="das-redacted-value"> [Not publishable] </span> </span>\t\t\t</div>\n </div>\n</section></section></section></section> <section data-cy="das-block" class="das-block GeneralPopulationHazardViaOralRoute "\n id="6a3d4273-d8b8-4a44-96d5-008c0f19f484"\n> <h3 class="das-block_label">\n General Population - Hazard via oral route\n </h3>\n <section data-cy="das-block" class="das-block SystemicEffects "\n id="275e318b-59e6-4f2f-99c9-431f1fdcf924"\n> <h3 class="das-block_label">\n Systemic effects\n </h3>\n <section data-cy="das-block" class="das-block LongTermStudy "\n id="4433f06d-22aa-4dfd-92f2-370e28bbd7a9"\n> <h3 class="das-block_label">\n Long term exposure\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label HazardAssessment">\n\t\t\tHazard assessment conclusion\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">DNEL (Derived No Effect Level)</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity ">\n\t\t<div class="das-field_label StDose">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value">1.6</span>\t\t<span class="unit">\n\t\t\t <span class="phrase ">mg/kg bw/day</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label MostSensitiveEndpoint">\n\t\t\tMost sensitive endpoint\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">repeated dose toxicity</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label OriginalStudy das-empty-value">\n\t\t\tRoute of original study\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n <section data-cy="das-block" class="das-block DNMELInfoWithRTR "\n id="5a4b6541-3ba3-41cd-89e2-f58b7301e919"\n> <h3 class="das-block_label">\n DNEL related information\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DerivationMethod das-empty-value">\n\t\t\tDNEL derivation method\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal ">\n\t\t<div class="das-field_label AssessmentFactor">\n\t\t\tOverall assessment factor (AF)\n\t\t</div>\n <div class="das-field_value">\n40 </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DoseDescriptorStartingPoint das-empty-value">\n\t\t\tDose descriptor starting point\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label DoseDescriptorStartRTR">\n\t\t\tModified dose descriptor starting point\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">NOAEL</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDoseRTR das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label JustificationRTR das-empty-value">\n\t\t\tExplanation for the modification of the dose descriptor starting point\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> [Empty] </span>\t\t\t</div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DoseResponseAF das-empty-value">\n\t\t\tAF for dose response relationship\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DoseResponseJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DiffInDurationAF das-empty-value">\n\t\t\tAF for differences in duration of exposure\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DiffInDurationJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label InterspeciesAF das-empty-value">\n\t\t\tAF for interspecies differences (allometric scaling)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label InterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesAF das-empty-value">\n\t\t\tAF for other interspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesAF das-empty-value">\n\t\t\tAF for intraspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DatabaseQualityAF das-empty-value">\n\t\t\tAF for the quality of the whole database\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DatabaseJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthUncertaintiesAF das-empty-value">\n\t\t\tAF for remaining uncertainties\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label OthUncertaintiesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n</section> <section data-cy="das-block" class="das-block ExplanationForHazardConclusion das-block_empty"\n id="c64e072f-576e-48ca-b5f4-c8810a543547"\n> <h3 class="das-block_label">\n Explanation for hazard conclusion\n </h3>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label JustificationAndComments das-empty-value">\n\t\t\tExplanation for hazard conclusion\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> <span class="das-redacted-icon"> <svg xmlns="http://www.w3.org/2000/svg" width="15.233" height="15.431" viewBox="0 0 15.233 15.431"> <g id="conf_flag" transform="translate(-107.9 -1.299)"> <path id="Path_394" data-name="Path 394" d="M109.832,9.81a38.965,38.965,0,0,0,5-1.761.688.688,0,0,1,.691-.043.617.617,0,0,1,.218.345,1.692,1.692,0,0,0,.1.276l.007-.011s0,0,0,.006l1.363-2.285a.245.245,0,0,1,.214-.126.242.242,0,0,1,.227.152l1.878,3.076a9.2,9.2,0,0,0,1.579-.445.5.5,0,0,0,.325-.475l-.021-5.158a.507.507,0,0,0-.6-.5c-.869.156-2.34.336-2.34.336-1.891.263-2.691-.436-2.963-.777a.876.876,0,0,1-.109-.167c-.381-.753-1.8-.954-3.2-.956a21.453,21.453,0,0,0-2.661.184,1.457,1.457,0,0,0-.687-.158,1.7,1.7,0,0,0-.282.023c-.383.062-.665.252-.68.473h0V15.233l0,.006v.148a.545.545,0,0,0,.122.344l.454.556a.542.542,0,0,0,.858-.024l.392-.539a.54.54,0,0,0,.1-.319V10.158l0-.141V9.81Zm0-7.612c2.308,2.456.5,6.4,0,7.377Z" transform="translate(0 0)" fill="#ed1156"/> <path id="Path_395" data-name="Path 395" d="M333.622,334.784l-5.485-8.977a.175.175,0,0,0-.161-.107.179.179,0,0,0-.126.053.161.161,0,0,0-.026.036l-5.359,8.983a.181.181,0,0,0,0,.192.174.174,0,0,0,.16.075h10.817a.173.173,0,0,0,.173-.077A.175.175,0,0,0,333.622,334.784Zm-5.164-.837a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-.5a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Zm0-1.763a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-2.876a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Z" transform="translate(-210.509 -318.31)" fill="#ed1156"/> </g> </svg> </span> <span class="das-redacted-value"> [Not publishable] </span> </span>\t\t\t</div>\n </div>\n</section></section> <section data-cy="das-block" class="das-block AcuteShortTermExposureStudy "\n id="14beb387-39bc-4808-b740-7fd2c0a69882"\n> <h3 class="das-block_label">\n Acute/short term exposure\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label HazardAssessment">\n\t\t\tHazard assessment conclusion\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">no hazard identified</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label MostSensitiveEndpoint das-empty-value">\n\t\t\tMost sensitive endpoint\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label OriginalStudy das-empty-value">\n\t\t\tRoute of original study\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n <section data-cy="das-block" class="das-block DNELInfoWithRouteToRouteWithExtrapolation "\n id="3954e4fb-7a63-4b72-98c0-076ea008c604"\n> <h3 class="das-block_label">\n DNEL related information\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DerivationMethod das-empty-value">\n\t\t\tDNEL derivation method\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OverallAssessmentFactor das-empty-value">\n\t\t\tOverall assessment factor (AF)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n\t <div class="das-field das-field_checkbox">\n\t\t<div class="das-field_label Extrapolated">\n\t\t\tDNEL extrapolated from long term DNEL\n\t\t</div>\n <div class="das-field_value">\n <span data-cy="das-value_checkbox-unchecked" class="das-value_checkbox-unchecked"></span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DoseDescriptorStartingPoint das-empty-value">\n\t\t\tDose descriptor starting point\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDose das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_select" class="das-field das-field_select das-field_no-value">\n\t\t<div class="das-field_label DoseDescriptorStartRTR das-empty-value">\n\t\t\tModified dose descriptor starting point\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </div>\n </div>\n\t\t<div data-cy="das-field_quantity" class="das-field das-field_quantity das-field_no-value">\n\t\t<div class="das-field_label StDoseRTR das-empty-value">\n\t\t\tValue\n\t\t</div>\n\t\t <div class="das-field_value">\n <span class="i6Value i6PhysicalQuantity">\n<span class="value"></span>\t\t<span class="unit">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n\t\t</span>\n </span>\n </div>\n\t\t</div>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label DoseDescriptorJustificationRTR das-empty-value">\n\t\t\tExplanation for the modification of the dose descriptor starting point\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> [Empty] </span>\t\t\t</div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DoseResponseAF das-empty-value">\n\t\t\tAF for dose response relationship\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DoseResponseJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label InterspeciesAF das-empty-value">\n\t\t\tAF for interspecies differences (allometric scaling)\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label InterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesAF das-empty-value">\n\t\t\tAF for other interspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label OthInterspeciesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesAF das-empty-value">\n\t\t\tAF for intraspecies differences\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label IntraspeciesJustifAF das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label DatabaseQualityDatabaseQualityAF das-empty-value">\n\t\t\tAF for the quality of the whole database\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label DatabaseQualityJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n\t <div data-cy="das-field_decimal" class="das-field das-field_decimal das-field_no-value">\n\t\t<div class="das-field_label OthUncertaintiesAF das-empty-value">\n\t\t\tAF for remaining uncertainties\n\t\t</div>\n <div class="das-field_value">\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </div>\n\t\t</div>\n <div data-cy="das-field_medium-text" data-cy="das-field_html-text" class="das-field das-field_text das-field_medium-text das-field_no-value">\n\t\t<div class="das-field_label UncertaintiesJustif das-empty-value">\n\t\t\tJustification\n\t\t</div>\n <div class="das-field_value das-field_value_medium">\n <p>\n\t\t<span data-cy="das-field-value-empty" class="das-empty-value">\n [Empty]\n\t\t</span>\n </p>\n </div>\n </div>\n</section> <section data-cy="das-block" class="das-block ExplanationForHazardConclusion das-block_empty"\n id="b437da16-ffa0-4282-8192-3ef69dfec64e"\n> <h3 class="das-block_label">\n Explanation for hazard conclusion\n </h3>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label JustificationAndComments das-empty-value">\n\t\t\tExplanation for hazard conclusion\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> <span class="das-redacted-icon"> <svg xmlns="http://www.w3.org/2000/svg" width="15.233" height="15.431" viewBox="0 0 15.233 15.431"> <g id="conf_flag" transform="translate(-107.9 -1.299)"> <path id="Path_394" data-name="Path 394" d="M109.832,9.81a38.965,38.965,0,0,0,5-1.761.688.688,0,0,1,.691-.043.617.617,0,0,1,.218.345,1.692,1.692,0,0,0,.1.276l.007-.011s0,0,0,.006l1.363-2.285a.245.245,0,0,1,.214-.126.242.242,0,0,1,.227.152l1.878,3.076a9.2,9.2,0,0,0,1.579-.445.5.5,0,0,0,.325-.475l-.021-5.158a.507.507,0,0,0-.6-.5c-.869.156-2.34.336-2.34.336-1.891.263-2.691-.436-2.963-.777a.876.876,0,0,1-.109-.167c-.381-.753-1.8-.954-3.2-.956a21.453,21.453,0,0,0-2.661.184,1.457,1.457,0,0,0-.687-.158,1.7,1.7,0,0,0-.282.023c-.383.062-.665.252-.68.473h0V15.233l0,.006v.148a.545.545,0,0,0,.122.344l.454.556a.542.542,0,0,0,.858-.024l.392-.539a.54.54,0,0,0,.1-.319V10.158l0-.141V9.81Zm0-7.612c2.308,2.456.5,6.4,0,7.377Z" transform="translate(0 0)" fill="#ed1156"/> <path id="Path_395" data-name="Path 395" d="M333.622,334.784l-5.485-8.977a.175.175,0,0,0-.161-.107.179.179,0,0,0-.126.053.161.161,0,0,0-.026.036l-5.359,8.983a.181.181,0,0,0,0,.192.174.174,0,0,0,.16.075h10.817a.173.173,0,0,0,.173-.077A.175.175,0,0,0,333.622,334.784Zm-5.164-.837a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-.5a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Zm0-1.763a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-2.876a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Z" transform="translate(-210.509 -318.31)" fill="#ed1156"/> </g> </svg> </span> <span class="das-redacted-value"> [Not publishable] </span> </span>\t\t\t</div>\n </div>\n</section></section></section></section> <section data-cy="das-block" class="das-block GeneralPopulationHazardForTheEyes "\n id="9592bf31-6f72-40ec-898f-d15828892c85"\n> <h3 class="das-block_label">\n General Population - Hazard for the eyes\n </h3>\n <section data-cy="das-block" class="das-block EyesLocalEffects "\n id="f36de165-de05-45e2-9919-c8f86fa9683e"\n> <h3 class="das-block_label">\n Local effects\n </h3>\n\t <div data-cy="das-field_select" class="das-field das-field_select ">\n\t\t<div class="das-field_label Conclusion">\n\t\t\tHazard assessment conclusion\n\t\t</div>\n\t <div class="das-field_value">\n\t\t<span class="das-field_value_pick-list">\n\t\t\t <span class="phrase ">low hazard (no threshold derived)</span>\n\t\t</span>\n </div>\n </div>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text das-field_no-value">\n\t\t<div class="das-field_label Comments das-empty-value">\n\t\t\tExplanation for hazard conclusion\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<span data-cy="das-field-value-empty" class="das-empty-value"> <span class="das-redacted-icon"> <svg xmlns="http://www.w3.org/2000/svg" width="15.233" height="15.431" viewBox="0 0 15.233 15.431"> <g id="conf_flag" transform="translate(-107.9 -1.299)"> <path id="Path_394" data-name="Path 394" d="M109.832,9.81a38.965,38.965,0,0,0,5-1.761.688.688,0,0,1,.691-.043.617.617,0,0,1,.218.345,1.692,1.692,0,0,0,.1.276l.007-.011s0,0,0,.006l1.363-2.285a.245.245,0,0,1,.214-.126.242.242,0,0,1,.227.152l1.878,3.076a9.2,9.2,0,0,0,1.579-.445.5.5,0,0,0,.325-.475l-.021-5.158a.507.507,0,0,0-.6-.5c-.869.156-2.34.336-2.34.336-1.891.263-2.691-.436-2.963-.777a.876.876,0,0,1-.109-.167c-.381-.753-1.8-.954-3.2-.956a21.453,21.453,0,0,0-2.661.184,1.457,1.457,0,0,0-.687-.158,1.7,1.7,0,0,0-.282.023c-.383.062-.665.252-.68.473h0V15.233l0,.006v.148a.545.545,0,0,0,.122.344l.454.556a.542.542,0,0,0,.858-.024l.392-.539a.54.54,0,0,0,.1-.319V10.158l0-.141V9.81Zm0-7.612c2.308,2.456.5,6.4,0,7.377Z" transform="translate(0 0)" fill="#ed1156"/> <path id="Path_395" data-name="Path 395" d="M333.622,334.784l-5.485-8.977a.175.175,0,0,0-.161-.107.179.179,0,0,0-.126.053.161.161,0,0,0-.026.036l-5.359,8.983a.181.181,0,0,0,0,.192.174.174,0,0,0,.16.075h10.817a.173.173,0,0,0,.173-.077A.175.175,0,0,0,333.622,334.784Zm-5.164-.837a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-.5a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Zm0-1.763a.21.21,0,0,1-.21.21h-.419a.21.21,0,0,1-.21-.21v-2.876a.21.21,0,0,1,.21-.21h.419a.21.21,0,0,1,.21.21Z" transform="translate(-210.509 -318.31)" fill="#ed1156"/> </g> </svg> </span> <span class="das-redacted-value"> [Not publishable] </span> </span>\t\t\t</div>\n </div>\n</section></section> <section data-cy="das-block" class="das-block AdditionalInformationGeneralPopulation "\n id="a2c2bca9-fbaf-4c19-b326-342b53d415d5"\n> <h3 class="das-block_label">\n Additional information - General Population\n </h3>\n\t <div data-cy="das-field_big-text" class="das-field das-field_big-text">\n\t\t<div class="das-field_label DiscussionGenPop das-empty-label">\n\t\t\t\n\t\t</div>\n\t\t\t<div class="das-field_value das-field_value_html">\n<p style="margin-bottom:0;top:0;margin-top:0;"> <font size="2" face="Arial">B.5.11.6 General population DNEL long-term inhalation by exposure via the environment </font> </p> <p style="margin-bottom:0;top:0;margin-top:0;"> </p> <p style="margin-bottom:0;top:0;margin-top:0;"> <font size="2" face="Arial">As discussed in section B.5.11.4 long-term repeated exposure to ethylbenzene has the potential to cause ototoxicity and devlopmental toxicity. </font> </p> <p style="margin-bottom:0;top:0;margin-top:0;"> </p> <p style="margin-bottom:0;top:0;margin-top:0;"> <font size="2" face="Arial">For ototoxicity: </font> </p> <p style="margin-bottom:0;top:0;margin-top:0;"> </p> <p style="margin-bottom:0;top:0;margin-top:0;"> <span style="font-family:Arial;font-size:10.0pt;"><font size="2" face="Arial">Repeated inhalation exposure to ethylbenzene vapor was irreversibly ototoxic in rats (Gagnaire et al., 2007).</font></span><font size="2" face="Arial"><span style="color:black;">Auditory dysfunction characterised by an elevation of hearing thresholds was localised in the mid frequencies and corresponded to the loss of cochlear outer hair cells, the sensory cells in the inner ear. Hearing loss and cell damage increased with exposure concentrations.</span><span style="font-family:Arial;font-size:10.0pt;">In this 90 day rat inhalation study (6 hours/day, 6 day/week) the NOAEC for ototoxicity was extrapolated to be 114 ppm (500 mg/m\xc2\xb3) based on destruction of outer hair cells in row 3 occurring already at 200 ppm. In contrast, no effect on hearing ability as indicated by audiometric thresholds was observed at 200 ppm. According to several case reports where hearing deficits in humans occupational exposed to organic solvents or from people after solvent abuse are described (for review cf Risk Assessment Reports on toluene and styrene), this rat data are taken to be relevant for humans.</span> </font> </p> <p style="top:0in;margin-left:0in;left:0in;margin-right:0in;margin-top:0in;margin-bottom:.0001pt;"> <span style="font-size:10.0pt;font-family:Arial;"><font face="Arial" size="2"> </font></span><font face="Arial" size="2"> </font> </p> <p style="top:0in;margin-left:0in;left:0in;margin-right:0in;margin-top:0in;margin-bottom:.0001pt;"> <span style="font-size:10.0pt;font-family:Arial;"><font face="Arial" size="2">Thus, this extrapolated NOAEC of 114 ppm (500 mg/m\xc2\xb3) is taken as dose descriptor for DNEL derivation of repeated dose toxicity for general population (consumer).</font></span><font face="Arial" size="2"> </font> </p> <p style="top:0in;margin-left:0in;left:0in;margin-right:0in;margin-top:0in;margin-bottom:.0001pt;"> <span style="font-size:10.0pt;font-family:Arial;"><font face="Arial" size="2"> </font></span><font face="Arial" size="2"> </font> </p> <p style="top:10.0pt;margin-top:10.0pt;"> <span style="font-size:10.0pt;font-family:Arial;"><font face="Arial" size="2">The extrapolated NOAEC of 114 ppm (500 mg/m\xc2\xb3) from the rat is (1) multiplied with a factor of 0.45 (for rat absorption percentage of 45%), divided by a divisor of 0.65 (for human absorption percentage after inhalation of 65%).</font></span><font face="Arial" size="2"><span style="color:black;">A factor for activity-driven differences of respiratory volumes is not necessary for the general population (via environment). Further differences regarding the experimental inhalation duration (6 hours/day, 6 days/week) and the environmental exposure conditions (24 hours/day, 7 days/week) have to be taken into consideration by factors of 6/24 and 6/7.</span> </font> </p> <p style="top:10.0pt;margin-top:10.0pt;"> <span style="font-size:10.0pt;color:black;font-family:Arial;"><font face="Arial" size="2">The calculation results in an adjusted inhalation starting point of</font></span><font face="Arial" size="2"> </font> </p> <span style="font-size:10.0pt;color:black;font-family:Arial;"><font face="Arial" size="2">114 x 0.45: 0.65 x 6/24 x 6/7 = 17ppm</font></span><font face="Arial" size="2"> </font> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-size:10.0pt;font-family:Arial;"><font face="Arial" size="2">In the overall assessment it has also be taken into consideration that the starting point to define ototoxicity is not auditory dysfunction but histopathological effects on the outer hair cells of the cochlea. Numerous investigations have shown that audiometric hearing deficits occur at higher exposure concentrations than (small) losses of hair cells in the outer row 3 of the cochlea. While the audiometric effects define the impact of ototoxicity for humans, the use of histopathological effects for the starting point implies a further conservative factor.</font></span><font face="Arial" size="2"> </font> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-size:10.0pt;font-family:Arial;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-size:10.0pt;font-family:Arial;">Hearing loss is not a specific effect for ethylbenzene but has also been found with other aromatic solvents like styrene, toluene, or xylenes. Detailed mechanistic studies, especially with styrene, have demonstrated that ototoxicity is exerted by the unmetabolized parent chemical. Studies in rats with styrene and toluene showed that hearing loss occurs within a few days of the start of exposure and although it does not increase in severity with prolongation of exposure, the initial effect is irreversible. According to Gagnaire et al. (2007) ethylbenzene led to maximal hearing impairment after about 4 weeks without further deterioration by prolongation of exposure.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-size:10.0pt;font-family:Arial;"> </span> </p> <span style="font-size:10.0pt;font-family:Arial;">Table B.6: Assessment factors and DNEL calculation for general population (consumer) (DIY) DNEL long-term inhalation for ototoxicity</span> <table border="1" style="border:none;" cellpadding="0" cellspacing="0"> <tr> <td style="border:solid windowtext 1.0pt;padding-top:0in;width:89.45pt;top:0in;padding-bottom:0in;padding-right:5.4pt;left:5.4pt;padding-left:5.4pt;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-size:10.0pt;font-family:Arial;">Uncertainties</span></p></td> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:0in;padding-left:5.4pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">AF</span></p></td> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:0in;padding-left:5.4pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Justification</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Interspecies differences</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial">For interspecies variability the assessment factors proposed by ECETOC (2003, 2010) are used. The dose descriptor was obtained from an inhalation study and is being used to derive an inhalation DNEL. It is therefore not necessary to apply an allometric scaling factor to take account of differences in basal metabolic rates between animals and humans. According to ECETOC the additional assessment factor of 2.5 to quantify other differences between animals and humans that could affect interspecies extrapolation is scientifically not justified and a factor of 1 is appropriate. On this basis the default factor of 1 to account for other species differences will be applied.</font></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Intraspecies differences</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">5</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial">There are no data to quantify variability in susceptibility to the effects of long-term exposure to ethylbenzene in the human population. However an analysis of assessment factors conducted by ECETOC (2003, 2010) showed that metabolic differences due to genetic polymorphisms do not to automatically require an increased assessment factor since alternative pathways of elimination are often present. This consideration, together with estimates of the upper 95th percentile of the distribution of variability in toxicokinetic and toxicodynamic parameters for populations of different ages, genders and disease states, supports use of an assessment factor of 5 to account for intraspecies variability within the general population. </font></p><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial"></font></p><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial">The default factor of 5 for the general population as proposed by ECETOC (2003, 2010) will therefore be used to take account of intraspecies variability.</font></p><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial"></font></p><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial">In total there is a combined inter- and intraspecies assessment factor of 5 that takes into account that the target tissue (outer hair cells in the cochlea, anatomical structure and blood supply of the cochlea) is identical in rats and humans. Furthermore, not hearing deficits but histopatological alterations of the cochlea were used as starting point. As histopathology is more sensitive than the physiological effects this is a conservative starting point per se.</font></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Differences in duration of exposure</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">The dose descriptor was obtained from a 90-day inhalation study. Although the DNEL is to be used to assess long-term repeated exposure there is strong evidence showing that the ototoxic effects of ethylbenzene have already occurred within the first four weeks of initial exposure and did not progress in severity with further exposure. On this basis, the duration of this study is adequate for the endpoint being studied and it is not necessary to apply a factor to take account of differences in duration of exposure.</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Dose response and endpoint specific/severity issues</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">As an extrapolated NOAEC for the most sensitive endpoint, i.e. histopathological alterations of cochlear hair cells, was used an additional assessment factor is not warranted. The study encompassed a range of concentrations and durations of exposure and provided reliable information on the dose-response relationship and severity of effect.</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Quality of database</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">The findings from the key study are supported by findings from several additional studies with similar aromatic solvents conducted to modern regulatory standards by separate groups of researchers. Therefore it is not necessary to apply an additional factor.</span><span>  </span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:426.1pt;padding-right:5.4pt;padding-top:0in;border-top:none;" colspan="3" valign="top" width="568"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Overall assessment factor:</span><span>  </span><span style="font-family:Arial;font-size:10.0pt;">5</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:426.1pt;padding-right:5.4pt;padding-top:0in;border-top:none;" colspan="3" valign="top" width="568"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Endpoint specific DNEL:</span><span> </span><span style="font-family:Arial;font-size:10.0pt;">17/5 = 3.4 ppm (24-hours) corresponding to 15 mg/m\xc2\xb3.</span></p></td> </tr> </table> <p style="top:0;margin-top:0;margin-bottom:0;"> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">For derivation of a worker-DNEL long-term based on reproductive effects in the a multi-generation study, effects observed for the time between weaning and puberty did not apply. On the other hand, effects occurring during pre- and postnatal phases have to be taken into account for exposures via the environment.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">According to section B.5.11.4.2a for definition of a DNEL two studies are available: A guideline 2-generation study with an indication of slight foetotoxicity (reduced foetal body weight and occasional increases in skeletal variations) in the presence of maternal toxicity with a NOAEC for foetal and maternal toxicity of 500 ppm and a preceding probe 1-generation reproduction toxicity study with a NOAEC of 100 ppm based on increased postnatal mortality and body weight gain depression in the offspring. This NOAEC of 100 ppm was governed by effects occurring after weaning when the offspring was directly exposed by inhalation. As a general strategy, the guideline 2-generation study with a large number of experimental animals should have precedence over the probe study with a more limited number of animals. But in order to derive a DNEL as conservative as possible for the general population exposed via the environment, the NOAEC of the probe 1-generation study will be used as starting point.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">In this probe reproductive toxicity study rats were exposed for 6 hours per day, 7 days per week. Since animals were exposed for 6 hours per day, whereas the exposure via the environment is continuous, it is necessary to adjust the starting point by a factor of 6/24. This NOAEC of 100 ppm from the rat is further multiplied with a factor of 0.45 (for rat absorption percentage of 45 %) and divided by 0.65 (for human absorption percentage of 65 %). An adjustment for physical activity is not necessary.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">The corrected starting point is therefore</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">100 x 6/24 x 0.45/0.65= 17.3 ppm.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <span style="font-family:Arial;font-size:10.0pt;">Table B.7: Assessment factors and calculation for general population DNEL long-term inhalation via environment for developmental toxicity based on generation studies </span> <table border="1" style="border:none;" cellpadding="0" cellspacing="0"> <tr> <td style="border:solid windowtext 1.0pt;padding-top:0in;width:89.45pt;top:0in;padding-bottom:0in;left:5.4pt;padding-right:5.4pt;padding-left:5.4pt;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Uncertainties</span></p></td> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:0in;padding-left:5.4pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">AF</span></p></td> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:0in;padding-left:5.4pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Justification</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Interspecies differences</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial">For interspecies variability the assessment factors proposed by ECETOC (2003, 2010) are used. The dose descriptor was obtained from an inhalation study and is being used to derive an inhalation DNEL. It is therefore not necessary to apply an allometric scaling factor to take account of differences in basal metabolic rates between animals and humans. According to ECETOC the additional assessment factor of 2.5 to quantify other differences between animals and humans that could affect interspecies extrapolation is scientifically not justified and a factor of 1 is appropriate. On this basis the default factor of 1 to account for other species differences will be applied.</font></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Intraspecies differences</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">5</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial">There are no data to quantify variability in susceptibility to the effects of long-term exposure to ethylbenzene in the human population. However an analysis of assessment factors conducted by ECETOC (2003, 2010) showed that metabolic differences due to genetic polymorphisms do not to automatically require an increased assessment factor since alternative pathways of elimination are often present. This consideration, together with estimates of the upper 95th percentile of the distribution of variability in toxicokinetic and toxicodynamic parameters for populations of different ages, genders and disease states, supports use of an assessment factor of 5 to account for intraspecies variability within the general population. </font></p><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial"></font></p><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial">The default factor of 5 for humans via environment as proposed by ECETOC will therefore be used to take account of intraspecies variability.</font></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Differences in duration of exposure</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">The NOAEC was derived from the 2-generation study covering the whole reproductive cycle. An assessment factor of 1 is therefore appropriate.</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Dose response and endpoint specific/severity issues</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">The NOAEC of 100 ppm was derived from generation studies covering the whole reproductive cycle. Therefore no additional assessment factor is necessary.</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Quality of database</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">The key study was conducted to modern regulatory standards and was adequately reported. On this basis the quality of the database is not considered to contribute uncertainty and it is therefore not necessary to apply an additional factor.</span><span>     </span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:426.1pt;padding-right:5.4pt;padding-top:0in;border-top:none;" colspan="3" valign="top" width="568"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Overall assessment factor:</span><span>  </span><span style="font-family:Arial;font-size:10.0pt;">5</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:426.1pt;padding-right:5.4pt;padding-top:0in;border-top:none;" colspan="3" valign="top" width="568"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Endpoint specific DNEL:</span><span> </span><span style="font-family:Arial;font-size:10.0pt;">17.3/5 = 3.5 ppm</span></p></td> </tr> </table> <p style="top:0;margin-top:0;margin-bottom:0;"> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">For prenatal effects the derivation of the DNEL is based on the prenatal toxicity study in rats of Saillenfait et al. (2003) at exposure concentrations of 100, 500, 1000, and 2000 ppm during gestation days 6-20 with a NOAEC of 500 ppm for an exposure regime of 6 h/d throughout gestation days 6-20.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">This NOAEC has to be adjusted by a factor of 6/24 to account for different daily exposure durations leading to 125 ppm. The dams were exposed every day during pregnancy. The NOAEC of 125 ppm from the rat is further multiplied with a factor of 0.45 (for rat absorption percentage of 45 %) and divided by 0.65 (for human absorption percentage of 65 %).</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">The adjusted starting point is therefore 86.5 ppm.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <span style="font-family:Arial;font-size:10.0pt;">Table B.8: Assessment factors and DNEL calculation for general population (via environment) DNEL long-term inhalation for developmental toxicity (prenatal toxicity studies) </span> <table border="1" style="border:none;" cellpadding="0" cellspacing="0"> <tr> <td style="border:solid windowtext 1.0pt;padding-top:0in;width:89.45pt;top:0in;padding-bottom:0in;left:5.4pt;padding-right:5.4pt;padding-left:5.4pt;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Uncertainties</span></p></td> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:0in;padding-left:5.4pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">AF</span></p></td> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:0in;padding-left:5.4pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Justification</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Interspecies differences</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">For interspecies variability the assessment factors proposed by ECETOC (2003, 2010) are used. The dose descriptor was obtained from an inhalation study and is being used to derive an inhalation DNEL. It is therefore not necessary to apply an allometric scaling factor to take account of differences in basal metabolic rates between animals and humans. According to ECETOC the additional assessment factor of 2.5 to quantify other differences between animals and humans that could affect interspecies extrapolation is scientifically not justified and a factor of 1 is appropriate. On this basis the default factor of 1 to account for other species differences will be applied.</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Intraspecies differences</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">5</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial">There are no data to quantify variability in susceptibility to the effects of long-term exposure to ethylbenzene in the human population. However an analysis of assessment factors conducted by ECETOC (2003, 2010) showed that metabolic differences due to genetic polymorphisms do not to automatically require an increased assessment factor since alternative pathways of elimination are often present. This consideration, together with estimates of the upper 95th percentile of the distribution of variability in toxicokinetic and toxicodynamic parameters for populations of different ages, genders and disease states, supports use of an assessment factor of 5 to account for intraspecies variability within the general population. </font></p><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial"></font></p><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial">The default factor of 5 for the general population as proposed by ECETOC will therefore be used to take account of intraspecies variability.</font></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Differences in duration of exposure</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">The NOAEC was derived from a prenatal toxicity study with an exposure regime from gestation day 6 up to the end of pregnancy at gestation day 20. An assessment factor of 1 is therefore appropriate.</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Dose response and endpoint specific/severity issues</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">As 500 ppm was a clear NOAEC for developmental effects, an assessment factor is not warranted in this respect.</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Quality of database</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">The key study was conducted to modern regulatory standards and was adequately reported. On this basis the quality of the database is not considered to contribute uncertainty and it is therefore not necessary to apply an additional factor.</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:426.1pt;padding-right:5.4pt;padding-top:0in;border-top:none;" colspan="3" valign="top" width="568"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Overall assessment factor:</span><span>  </span><span style="font-family:Arial;font-size:10.0pt;">5</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:426.1pt;padding-right:5.4pt;padding-top:0in;border-top:none;" colspan="3" valign="top" width="568"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Endpoint specific DNEL:</span><span> </span><span style="font-family:Arial;font-size:10.0pt;">174/5 = 17.3 ppm (8-hour) corresponding to 76 mg/m\xc2\xb3</span></p></td> </tr> </table> <p style="top:0;margin-top:0;margin-bottom:0;"> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">B.5.11.6h. Selection of DNEL long-term inhalation for the general population (via environment)</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">In conclusion a DNEL long-term for the general population by exposure via the environment of 3.4 ppm is proposed based on ototoxic effects. This DNEL is very similar to that derived from toxic effects observed in generation studies being 3.5 ppm.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">B.5.11.7 General population (via environment) DNEL long-term oral route</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">For deriving a DNEL long-term oral route for the general population (via environment) two approaches should be considered:</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">starting from the lowest DNEL long-term inhalation route (ref section B.5.11.7b) for the general population (via environment)</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">starting from the rat 90-day oral study (Mellert et al., 2007) thereby obviating a route-to-route extrapolation.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">a) starting from the DNEL long-term inhalation route for the general population (via environment)</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">The lowest general population DNEL long-term for the inhalation route via environment was calculated to be 3.4 ppm, corresponding to 15 mg/m\xc2\xb3 (see section B.5.11.7.b) based on ototoxicity. A respiratory volume of 20 m\xc2\xb3/person/d is used for the general population (ECHA, 2008) and an uptake by inhalation of 65%. This leads to an internal body burden of</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">15 x 20 x 0.65 = 195 mg/person/d, corresponding to 2.8 mg/kg/d.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">After oral exposure up to 92% of the ethylbenzene dose could be recovered as urinary metabolites in rabbits (El Masry et al., 1952) and 84% in urine and feces of rats (Climie et al., 1983); therefore 100% absorption by oral exposure is taken for humans as default.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">Thus, for the general population (via environment) the DNEL long-term oral derived from that by inhalation is 2.8 mg/kg/d.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">b) starting from the rat 90-day oral study</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">An increase in liver and kidney weights of rats and mice without histopathological alterations has been found in several studies. These changes are most probably related to enzyme induction. The NOAEL in a guideline oral 90 day study with rats was 75 mg/kg bw/d (LOAEL 250 mg/kg bw/d) based on indications for a mild regenerative anemia and liver changes indicative of microsomal enzyme induction.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">The animals were dosed daily by gavage. A 84% oral absorption is used for rats (Climie et al., 1983) and 100% for humans as conservative default leading to an internal dose of 75 x 0.84 = 63 mg/kg/d as starting point.</span> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;"> </span> </p> <span style="font-family:Arial;font-size:10.0pt;">Table B.9: Assessment factors and DNEL calculation for the general population (via environment) long-term oral (based on rat oral study) </span> <table border="1" style="border:none;" cellpadding="0" cellspacing="0"> <tr> <td style="border:solid windowtext 1.0pt;padding-top:0in;width:89.45pt;top:0in;padding-bottom:0in;left:5.4pt;padding-right:5.4pt;padding-left:5.4pt;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Uncertainties</span></p></td> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:0in;padding-left:5.4pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">AF</span></p></td> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:0in;padding-left:5.4pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Justification</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Interspecies differences</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">4</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">For interspecies variability the assessment factors proposed by ECETOC (2003, 2010) are used. The dose descriptor was obtained from an oral study and is being used to derive an inhalation DNEL. Therefore an allometric scaling factor of 4 is used to take account of differences in basal metabolic rates between animals and humans. According to ECETOC the additional assessment factor of 2.5 to quantify other differences between animals and humans that could affect interspecies extrapolation is scientifically not justified and a factor of 1 is appropriate. On this basis the default factor of 1 to account for other species differences will be applied.</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Intraspecies differences</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">5</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial">There are no data to quantify variability in susceptibility to the effects of long-term exposure to ethylbenzene in the human population. However an analysis of assessment factors conducted by ECETOC (2003, 2010) showed that metabolic differences due to genetic polymorphisms do not to automatically require an increased assessment factor since alternative pathways of elimination are often present. This consideration, together with estimates of the upper 95th percentile of the distribution of variability in toxicokinetic and toxicodynamic parameters for populations of different ages, genders and disease states, supports use of an assessment factor of 5 to account for intraspecies variability within the general population.</font><font face="Arial"> </font></p><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial"></font></p><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial">The default factor of 5 for the general population as proposed by ECETOC will therefore be used to take account of intraspecies variability.</font></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Differences in duration of exposure</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">2</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><font size="2" face="Arial">The NOAEL was obtained from a 90-day oral rat study. For extrapolation to chronic exposure an assessment factor of 2 is therefore appropriate according to REACH (2008) and ECETOC (2003, 2010).</font></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Dose response and endpoint specific/severity issues</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">As 75 mg/kg/d was a clear NOAEL with a dose response relationship for toxicologically relevant effects at higher doses, an assessment factor is not warranted in this respect.</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:89.45pt;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="119"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Quality of database</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:41.95pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="56"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">1</span></p></td> <td style="left:none;border-right:solid windowtext 1.0pt;padding-bottom:0in;top:none;padding-left:5.4pt;border-bottom:solid windowtext 1.0pt;width:294.7pt;border-left:none;padding-right:5.4pt;padding-top:0in;border-top:none;" valign="top" width="393"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">The key study was conducted to modern regulatory standards and was adequately reported. On this basis the quality of the database is not considered to contribute uncertainty and it is therefore not necessary to apply an additional factor.</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:426.1pt;padding-right:5.4pt;padding-top:0in;border-top:none;" colspan="3" valign="top" width="568"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Overall assessment factor:</span><span>  </span><span style="font-family:Arial;font-size:10.0pt;">40</span></p></td> </tr> <tr> <td style="border:solid windowtext 1.0pt;left:5.4pt;padding-bottom:0in;top:none;padding-left:5.4pt;width:426.1pt;padding-right:5.4pt;padding-top:0in;border-top:none;" colspan="3" valign="top" width="568"><p style="top:0;margin-top:0;margin-bottom:0;"><span style="font-family:Arial;font-size:10.0pt;">Endpoint specific DNEL:</span><span> </span><span style="font-family:Arial;font-size:10.0pt;">63/40 = 1.6 mg/kg/d</span></p></td> </tr> </table> <p style="top:0;margin-top:0;margin-bottom:0;"> </p> <p style="top:0;margin-top:0;margin-bottom:0;"> <span style="font-family:Arial;font-size:10.0pt;">In conclusion, the DNEL long-term for the general population (via environment) by oral exposure is 1.6 mg/kg/d.</span> </p>\t\t\t</div>\n </div>\n</section> </article>\n </div>\n </div>\n </div>\n </div>\n\n <div id="das-totop" class="das-totop">\n <button class="das-button">\n <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path d="M34.9 289.5l-22.2-22.2c-9.4-9.4-9.4-24.6 0-33.9L207 39c9.4-9.4 24.6-9.4 33.9 0l194.3 194.3c9.4 9.4 9.4 24.6 0 33.9L413 289.4c-9.5 9.5-25 9.3-34.3-.4L264 168.6V456c0 13.3-10.7 24-24 24h-32c-13.3 0-24-10.7-24-24V168.6L69.2 289.1c-9.3 9.8-24.8 10-34.3.4z"/></svg>\n Back to top\n </button>\n </div>\n </body>\n</html>\n' |